Engineering of Functional Skeletal Tissues

1. Front Matter

   Pages i-xiii

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2. Stem Cells and the Art of Mesenchymal Maintenance

   • Kevin C. Hicok, Marc H. Hedrick

   Pages 1-16

3. Osteogenic Growth Factors and Cytokines and Their Role in Bone Repair

   • Louis C. Gerstenfeld, Cory M. Edgar, Sanjeev Kakar, Kimberly A. Jacobsen, Thomas A. Einhorn

   Pages 17-45

4. Bone Allograft Safety and Performance

   • Calin S. Moucha, Regis L. Renard, Ankur Gandhi, Sheldon S. Lin, Rocky S. Tuan

   Pages 46-54

5. Biodegradable Orthopedic Implants

   • Hansoo Park, Johnna S. Temenoff, Antonios G. Mikos

   Pages 55-68

6. Titanium Fiber Mesh: A Nondegradable Scaffold Material

   • Juliette van den Dolder, John A. Jansen

   Pages 69-80

7. Engineering Polymeric Scaffolds for Bone Grafts

   • Martha W. Betz, Diana M. Yoon, John P. Fisher

   Pages 81-94

8. Injectable Scaffolds for Bone and Cartilage Regeneration

   • Claudio Migliaresi, Antonella Motta, Anthony T. DiBenedetto

   Pages 95-109

9. Motion and Bone Regeneration

   • Ching-Chang Ko, Martha J. Somerman, Kai-Nan An

   Pages 110-128

10. Dental Applications of Bone Biology

    • Thomas W. Oates, David L. Cochran

    Pages 129-140

11. Multiscale Computational Engineering of Bones: State-of-the-Art Insights for the Future

    • Melissa L. Knothe Tate

    Pages 141-160

12. Back Matter

    Pages 161-178

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The science of bone replacement has greatly advanced in recent decades, but replacing bone with bone tissue rather than with metallic components remains in early development. The current volume, third in the series Topics in Bone Biology, deals with problems inherent in inducing the body cells to accomplish bone tissue repair, to degrade devices introduced to provide initial mechanical support, and to attract and stimulate bone f- mation. It is therefore logical that Chapter 1, by Hicok and Hedrick, deals with stem cells, i. e. , pluripotential cells that may differentiate into cartilage and bone cells. The chapter begins with a description of how stem cells may be harvested; the limitations of autologous, embryonic, and adult stem cells; and the need to expand the harvested cells in culture. The authors then discuss the in? uences of the body environment on implanted cells and on the scaffolds that need to be introduced. They emphasize the need for adequate oxygenation and for rapid integration with the vascular system of the host/patient. Stem-cell-engineered cartilage is discussed at some length, along with the need for stem-cell-engineered ligaments and tendons. The chapter concludes with an analysis of what needs to be learned to make stem-cell-engineered bone tissue a reality. In Chapter 2, Gerstenfeld and colleagues review osteogenic growth factors and cytokines, soluble proteins that regulate postnatal bone repair. These molecules are of importance because many are targets of efforts to promote therapeutic bone healing and repair.

• bioengineering
• bone
• cartilage
• cells
• rehabilitation
• skeletal function and rehabilitation
• skeletal tissue engineering
• tissue
• tissue engineering

• University of Connecticut Health Center, Farmington, USA

  Felix Bronner

• Department of Biological Sciences, University of Delaware, Newark, USA

  Mary C. Farach-Carson

• Department of Bioengineering, Rice University, Houston, USA

  Antonios G. Mikos

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