Breast Cancer

1. Front Matter

   Pages i-xii

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2. The Theory of the Sick Lobe

   • Tibor Tot

   Pages 1-17

3. Lobar Anatomy of Human Breast and Its Importance for Breast Cancer

   • James J. Going

   Pages 19-37

4. Breast Cancer May Originate In Utero: The Importance of the Intrauterine Environment for Breast Cancer Development

   • Fei Xue, Karin B. Michels

   Pages 39-52

5. Genetic Alterations in Normal and Malignant Breast Tissue

   • Chanel E. Smart, Peter T. Simpson, Ana Cristina Vargas, Sunil R. Lakhani

   Pages 53-66

6. The Role of Ductal Lavage: A Cautionary Tale

   • Susan M. Love, Dixie J. Mills

   Pages 67-77

7. The Distribution of the Earliest Forms of Breast Carcinoma

   • Maria P. Foschini, Vincenzo Eusebi

   Pages 79-85

8. The Implications of the Imaging Manifestations of Multifocal and Diffuse Breast Cancers

   • László K. Tabár, Peter B. Dean, Tibor Tot, Nadja Lindhe, Mats Ingvarsson, Amy Ming-Fang Yen

   Pages 87-152

9. Lobar Ultrasound of the Breast

   • Dominique Amy

   Pages 153-162

10. The Lobar Distribution of the Lesions in Breast Carcinoma: Ductoscopy and Surgery

    • William C. Dooley

    Pages 163-166

11. Stop Breast Cancer Now! Imagining Imaging Pathways Toward Search, Destroy, Cure, and Watchful Waiting of Premetastasis Breast Cancer

    • Richard Gordon

    Pages 167-203

12. Epilogue: The Diseased Breast Lobe in the Context of X-Chromosome Inactivation and Differentiation Waves

    • Richard Gordon

    Pages 205-210

13. Back Matter

    Pages 211-216

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The theory of the sick lobe states that breast carcinoma is a lobar disease developing most often within a single lobe, meaning that, at an early stage, breast carcinoma occupies a limited, anatomically well-defined portion of the breast. This theory unites observed patterns from the genetic, developmental and morphological perspectives, into an overall concept. Breast Cancer: A Lobar Disease, presents this hypothesis and its consequences. The body of evidence, pro and contra, generated in recent years will be presented in this volume. The chapters, all authored by leading experts in their respective areas, gather evidence from the perspectives of epidemiology, genetics, radiology, anatomy, developmental biology, morphology, endoscopy, ultrasound and therapeutics to give the reader a full picture of recent developments regarding the sick lobe hypothesis. Tibor Tot, MD PhD is Head of the Pathology and Clinical Cytology Department at the Central Hospital of Falun, in Sweden; breast cancer expert of the National Board of Health and Welfare in Sweden; and regular Course Director of the breast pathology program, the official educational program for Swedish residents in clinical pathology, oncology, radiology and surgery.

From the reviews:

“This is a very reasonable objective as the etiology of breast cancer remains uncertain. The book meets this objective to a degree, as it brings forward much useful information regarding the concept of the ‘sick lobe’. It would be of interest to anyone studying the biology of breast cancer. The book covers labor anatomy, embryology, molecular aspects of labor development and cancer formation. … Overall, most chapters are interesting and likely will add to the fund of knowledge of even experienced breast cancer practitioners.” (Frederick M. Dirbas, Doody’s Review Service, October, 2012)

• Department of Pathology and Clinical Cyt, Falun Central Hospital, Falun, Sweden

  Tibor Tot

Tibor Tot, MD PhD is Head of the Pathology and Clinical Cytology Department at the Central Hospital of Falun, in Sweden; breast cancer expert of the National Board of Health and Welfare in Sweden; and regular Course Director of the breast pathology program, the official educational program for Swedish residents in clinical pathology, oncology, radiology and surgery.

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