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Investigative Electrocardiography in Epidemiological Studies and Clinical Trials

  • Book
  • © 2007

Overview

Authors:
  1. Pentti Rautaharju

    1. Wake Forest University School of Medicine, Winston-Salem, USA

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    You can also search for this author in PubMed   Google Scholar

  2. Farida Rautaharju

    1. Covance Cardiac Safety Services, Reno, USA

    View author publications

    You can also search for this author in PubMed   Google Scholar

  • Comprehensive, penetrating, critical analysis of problems in such areas as QT prolongation in clinical drug trials, left ventricular hypertrophy, myocardial ischemia/infarction, epidemiological consideration of relative risks associated with ECG abnormalities

  • Includes supplementary material: sn.pub/extras

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-x
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  2. Investigative Electrocardiography in Epidemiological Studies and Clinical Trials

    1. Front Matter

      Pages 1-1
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    2. Cardiac Excitation and Repolarization

      Pages 3-17

    3. Electrocardiographic Lead Systems

      Pages 18-28

    4. Normal and Arrhythmogenic Ionic Channel Mechanism

      Pages 29-44

    5. Heart Rate and Heart Rate Variability

      Pages 45-67

    6. Methodological Considerations in Heart Rate Variability Analysis

      Pages 68-73

    7. Supraventricular Dysrhythmias

      Pages 74-99

    8. Ectopic Ventricular Activity

      Pages 100-112

    9. Record Length, Spontaneous Variability and Suppression of Ectopic Ventricular Complex Activity by Drugs

      Pages 113-115

    10. Left Ventricular Hypertrophy

      Pages 116-149

    11. Normal Standards for Cornell Voltage, Cornell Product and Sokolow-Lyon Voltage

      Pages 150-153

    12. Prolonged Ventricular Excitation

      Pages 154-165

    13. Old Myocardial Infarction

      Pages 166-178

    14. Attributable Risk

      Pages 179-182

    15. Primary Repolarization Abnormalities

      Pages 183-200

    16. Procedures for Determination of the Spatial QRS/T Angle from Conventional ECG Measurements

      Pages 201-201

    17. QT Prolongation and QT Dispersion — a Critical Evaluation

      Pages 202-228

  3. Normal ECG Standards for Adults by Gender, Age, and Ethnicity

    1. Front Matter

      Pages 229-229
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    2. ECG Intervals: Tables

      Pages 231-235
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Keywords

About this book

This book on investigative electrocardiography is addressed to investigators who are using electrocardiology as a research tool in epidemiological or clinical research or in investigations on possible adverse responses of new pharmacological agents. The primary emphasis of the book is on prognostic implications of ECG abnormalities in the conditions covered, including the prevalence and incidence of ECG abnormalities in contrasting populations. We excluded from our book cardiac disorders with a relatively low population pre- lence that otherwise may be of great clinical interest. We also decided to exclude acute myocardial infarction because we had only limited resources available on this topic from our population studies and from those clinical trials in which we have personally p- ticipated in the classi? cation of trial endpoints within the framework of an ECG research center. Clinical trials are a relatively new area of electrocardiology. However, electrocard- graphy has become a most valuable research tool in clinical trials and in investigations on morbidity and mortality risk associated with various clinical and subclinical con- tions. It has also become a crucial research tool in investigating adverse cardiac events associated with administration of new drugs. Evaluation of QT prolongation plays a central role in these investigations. As a possible marker of malignant arrhythmias, it is used by regulating agencies in their decision process for approval of new pharmacolo- cal agents.

Reviews

From the reviews:

"This book reviews common ECG abnormalities in various populations and focuses on the prevalence and incidence of these abnormalities as well as the prognostic implications of the findings. It uniquely provides an extensive series of tables listing normal standard of ECG intervals, amplitudes, and vectors in various populations … . Investigators using electrocardiography as a research tool are the intended audience … . This is a thorough book that will be useful to its targeted audience." (Marc N. Saad, Doody’s Review Service, August, 2008)

Authors and Affiliations

  • Wake Forest University School of Medicine, Winston-Salem, USA

    Pentti Rautaharju

  • Covance Cardiac Safety Services, Reno, USA

    Farida Rautaharju

About the authors

The authors have closely collaborated for over a quarter of a Century in operating an academic ECG Center that has been in charge of ECG analysis of all major national health surveys conducted by the US National Center for Health Statistics, a series of large cardiovascular observational studies and clinical trials conducted by the US National Heart, Lung, and Blood Institute and several large clinical trials sponsored by pharmaceutical industry.

Bibliographic Information

  • Book Title: Investigative Electrocardiography in Epidemiological Studies and Clinical Trials

  • Authors: Pentti Rautaharju, Farida Rautaharju

  • DOI: https://doi.org/10.1007/978-1-84628-481-6

  • Publisher: Springer London

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag London 2007

  • Hardcover ISBN: 978-1-84628-465-6Published: 28 December 2006

  • Softcover ISBN: 978-1-4471-5962-9Published: 20 September 2014

  • eBook ISBN: 978-1-84628-481-6Published: 12 March 2007

  • Edition Number: 1

  • Number of Pages: X, 289

  • Topics: Cardiology, Cardiac Surgery, Vascular Surgery, Epidemiology, Internal Medicine

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