Methods in Pharmacology and Toxicology

Optimization in Drug Discovery

In Vitro Methods

Editors: Caldwell, Gary W., Yan, Zhengyin (Eds.)

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  • Provides updated variations on assays as well as numerous new protocols for drug discovery optimization
  • Features readily reproducible methods and protocols that are lab-tested and successful
  • Includes expert tips and key implementation advice
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eBook $129.00
price for USA in USD (gross)
  • ISBN 978-1-62703-742-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-1-62703-741-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.00
price for USA in USD
  • ISBN 978-1-4939-6070-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve “drug-like” characteristics in addition to efficacy properties and good safety profiles of drug candidates.

Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.

Table of contents (34 chapters)

Table of contents (34 chapters)

Buy this book

eBook $129.00
price for USA in USD (gross)
  • ISBN 978-1-62703-742-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-1-62703-741-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.00
price for USA in USD
  • ISBN 978-1-4939-6070-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Optimization in Drug Discovery
Book Subtitle
In Vitro Methods
Editors
  • Gary W. Caldwell
  • Zhengyin Yan
Series Title
Methods in Pharmacology and Toxicology
Copyright
2014
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-62703-742-6
DOI
10.1007/978-1-62703-742-6
Hardcover ISBN
978-1-62703-741-9
Softcover ISBN
978-1-4939-6070-5
Series ISSN
1557-2153
Edition Number
2
Number of Pages
XVII, 597
Number of Illustrations
64 b/w illustrations, 49 illustrations in colour
Topics