Tissue-Protective Cytokines
Methods and Protocols
Editors: Ghezzi, Pietro, Cerami, Anthony (Eds.)
Free Preview- Covers many aspects of the tissue-protective actions of erythropoietin (EPO) and other cytokines
- Collects methods of models where cytokine molecules can be characterized
- Presents notes on troubleshooting and avoiding pitfalls
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- About this book
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While many cytokines are known for their inflammatory action, there is a growing interest in the tissue-protective effects of some cytokines. The prototypic tissue-protective cytokine is EPO. Initially described as neuro-protective, it is beneficial in animal models of ischemic and other types of injury. Scientists had to overcome the notion that EPO had only erythropoietic actions, was only produced by the kidney, and that its receptor was only present in erythroid progenitor cells. The use of in vitro and in vivo disease models was essential to demonstrate the protective effects of EPO. Reproducible models will be needed for the further study of the mechanism of action of EPO and for the identification of other tissue-protective cytokines.
In Tissue-Protective Cytokines: Methods and Protocols, expert researchers in the field detail the key models that have been used to characterize the tissue-protective actions of cytokines. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, provide step-by-step laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Thorough and intuitive, Tissue Protective Cytokines: Methods and Protocols aids scientists in continuing to study tissue-protection that will be a new field of interest of cytokine biology, both in discovering novel actions of known cytokines and in developing new drugs.
- Table of contents (19 chapters)
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Erythropoietin and Engineered Innate Repair Activators
Pages 1-11
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Epo and Non-hematopoietic Cells: What Do We Know?
Pages 13-41
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Tissue-Protective Cytokines: Structure and Evolution
Pages 43-58
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The Regenerative Activity of Interleukin-6
Pages 59-77
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Brain Ischemic Injury in Rodents: The Protective Effect of EPO
Pages 79-101
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Table of contents (19 chapters)
- Download Preface 1 PDF (73.9 KB)
- Download Sample pages 1 PDF (871 KB)
- Download Table of contents PDF (91.8 KB)
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Bibliographic Information
- Bibliographic Information
-
- Book Title
- Tissue-Protective Cytokines
- Book Subtitle
- Methods and Protocols
- Editors
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- Pietro Ghezzi
- Anthony Cerami
- Series Title
- Methods in Molecular Biology
- Series Volume
- 982
- Copyright
- 2013
- Publisher
- Humana Press
- Copyright Holder
- Springer Science+Business Media, LLC
- eBook ISBN
- 978-1-62703-308-4
- DOI
- 10.1007/978-1-62703-308-4
- Hardcover ISBN
- 978-1-62703-307-7
- Softcover ISBN
- 978-1-4939-6244-0
- Series ISSN
- 1064-3745
- Edition Number
- 1
- Number of Pages
- XI, 328
- Topics
