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Quantitative Trait Loci (QTL)

Methods and Protocols

  • Book
  • © 2012

Overview

Editors:
  1. Scott A. Rifkin

    1. University of California, San Diego, La Jolla, USA

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  • A practical resource for researchers interested in link between phenotypic and genotypic variation
  • Provides step-by-step detail essentail for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 871)

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Table of contents (16 protocols)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Setting Up Mapping Populations

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Backcross Populations and Near Isogenic Lines

      • Rik Kooke, Erik Wijnker, Joost J. B. Keurentjes
      Pages 3-16

    3. F2 Designs for QTL Analysis

      • Yuan-Ming Zhang
      Pages 17-29

    4. Design and Construction of Recombinant Inbred Lines

      • Daniel A. Pollard
      Pages 31-39

    5. Two Flavors of Bulk Segregant Analysis in Yeast

      • Maitreya J. Dunham
      Pages 41-54

    6. Selecting Markers and Evaluating Coverage

      • Matthew A. Cleveland, Nader Deeb
      Pages 55-71

  3. Identifying Quantitative Trait Loci

    1. Front Matter

      Pages 73-73
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    2. Composite Interval Mapping and Multiple Interval Mapping: Procedures and Guidelines for Using Windows QTL Cartographer

      • Luciano Da Costa E. Silva, Shengchu Wang, Zhao-Bang Zeng
      Pages 75-119

    3. Design Database for Quantitative Trait Loci (QTL) Data Warehouse, Data Mining, and Meta-Analysis

      • Zhi-Liang Hu, James M. Reecy, Xiao-Lin Wu
      Pages 121-144

    4. Meta-analysis of QTL Mapping Experiments

      • Xiao-Lin Wu, Zhi-Liang Hu
      Pages 145-171

  4. Extending the Power of Quantitative Trait Locus Analysis

    1. Front Matter

      Pages 173-173
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    2. Using eQTLs to Reconstruct Gene Regulatory Networks

      • Lin S. Chen
      Pages 175-189

    3. Estimation and Interpretation of Genetic Effects with Epistasis Using the NOIA Model

      • José M. Álvarez-Castro, Örjan Carlborg, Lars Rönnegård
      Pages 191-204

    4. Identifying QTL for Multiple Complex Traits in Experimental Crosses

      • Samprit Banerjee, Nengjun Yi
      Pages 205-225

    5. Functional Mapping of Developmental Processes: Theory, Applications, and Prospects

      • Kiranmoy Das, Zhongwen Huang, Jingyuan Liu, Guifang Fu, Jiahan Li, Yao Li et al.
      Pages 227-243

    6. Statistical Models for Genetic Mapping in Polyploids: Challenges and Opportunities

      • Jiahan Li, Kiranmoy Das, Jingyuan Liu, Guifang Fu, Yao Li, Christian Tobias et al.
      Pages 245-261

  5. Case Studies

    1. Front Matter

      Pages 263-263
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    2. eQTL

      • Lun Li, Xianghua Zhang, Hongyu Zhao
      Pages 265-279

    3. Genetic Mapping of Quantitative Trait Loci for Disease-Related Phenotypes

      • Marcella Devoto, Mario Falchi
      Pages 281-311
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Keywords

About this book

Over the last two decades advances in genotyping technology, and the development of quantitative genetic analytical techniques have made it possible to dissect complex traits and link quantitative variation in traits to allelic variation on chromosomes or quantitative trait loci (QTLs). In Quantitative Trait Loci (QTLs):Methods and Protocols, expert researchers in the field detail methods and techniques that focus on specific components of the entire process of quantitative train loci experiments. These include methods and techniques for the mapping populations, identifying quantitative trait loci, extending the power of quantitative trait locus analysis, and case studies. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.

 

Thorough and intuitive, Quantitative Trait Loci (QTLs):Methods and Protocols aids scientists in the further study of the links between phenotypic and genotypic variation in fields from medicine to agriculture, from molecular biology to evolution to ecology.

Editors and Affiliations

  • University of California, San Diego, La Jolla, USA

    Scott A. Rifkin

Bibliographic Information

  • Book Title: Quantitative Trait Loci (QTL)

  • Book Subtitle: Methods and Protocols

  • Editors: Scott A. Rifkin

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-61779-785-9

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2012

  • Hardcover ISBN: 978-1-61779-784-2Published: 09 May 2012

  • Softcover ISBN: 978-1-4939-5832-0Published: 23 August 2016

  • eBook ISBN: 978-1-61779-785-9Published: 08 May 2012

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XI, 331

  • Topics: Human Genetics

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