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Oxidative Stress in Cancer Biology and Therapy

  • Book
  • © 2012

Overview

Editors:
  1. Douglas R. Spitz

    1. Free Radical & Radiation Biology, Graduate Program, University of Iowa, Iowa City, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Kenneth J. Dornfeld

    1. Duluth Clinic, Radiation Oncology, University of Minnesota, Duluth, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Koyamangalath Krishnan

    1. James H. Quillen College of Medicine, Internal Medicine, East Tennessee State University, Johnson City, USA

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    You can also search for this editor in PubMed   Google Scholar

  4. David Gius

    1. Radiation Oncology, Cancer Biology and Pediatrics, Vanderbilt Medical School, Nashville, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides highly informative emerging perspectives
  • Represents an outstanding resource for both basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy
  • Written by experts
  • Includes supplementary material: sn.pub/extras

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Oxidative Stress and Tumor Response (Preclinical)

    1. Front Matter

      Pages 1-1
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    2. Mitochondria-Mediated Oxidative Stress and Cancer Therapy

      • Iman M. Ahmad, Maher Y. Abdalla
      Pages 3-19

    3. The Role of Akt Pathway Signaling in Glucose Metabolism and Metabolic Oxidative Stress

      • Andrean L. Simons, Kevin P. Orcutt, Joshua M. Madsen, Peter M. Scarbrough, Douglas R. Spitz
      Pages 21-46

    4. Enhancement of Cancer Therapy Using Ketogenic Diet

      • Melissa A. Fath, Andrean L. Simons, Jeffrey Erickson, Mark E. Anderson, Douglas R. Spitz
      Pages 47-58

    5. Superoxide Dismutase and Cancer Therapy

      • Melissa L. Teoh-Fitzgerald, Frederick E. Domann
      Pages 59-84

    6. Radiosensitization and Chemosensitization of Multicellular Tumor Spheroids by 2-Deoxy-d-Glucose is Stimulated by a Combination of TNFα and Glucose Deprivation-Induced Oxidative Stress

      • Divya Khaitan, Bilikere S. Dwarakanath
      Pages 85-94

  3. Oxidative Stress in Normal Tissue Response (Preclinical)

    1. Front Matter

      Pages 95-95
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    2. Chemotherapy-Induced Oxidative Stress in Nontargeted Normal Tissues

      • Paiboon Jungsuwadee, Mary Vore, Daret K. St. Clair
      Pages 97-129

    3. Tetrahydrobiopterin and Endothelial Nitric Oxide Synthase: Implications for Radiation-Induced Endothelial Dysfunction and Normal Tissue Radiation Injury

      • Maaike Berbée, Qiang Fu, K. Sree Kumar, Martin Hauer-Jensen
      Pages 131-147

    4. Amifostine and the Endogenous Cellular Antioxidant Enzyme Manganese Superoxide Dismutase in Radioprotection

      • Jeffrey S. Murley, Yasushi Kataoka, David J. Grdina
      Pages 149-168

    5. Redox Regulation of Stem Cell Compartments: The Convergence of Radiation-Induced Normal Tissue Damage and Oxidative Stress

      • Ruth K. Globus, Vincent Caiozzo, Munjal Acharya, John R. Fike, Charles Limoli
      Pages 169-192

  4. Imaging Redox Changes and Therapeutic Response (Preclinical and Clinical)

    1. Front Matter

      Pages 193-193
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    2. Functional Imaging in the Assessment of Normal Tissue Injury Following Radiotherapy

      • Kenneth J. Dornfeld, Yusuf Menda
      Pages 195-215

  5. Oxidative Stress in Tumor Response (Clinical)

    1. Front Matter

      Pages 217-217
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    2. Histone Deacetylase Inhibitors, Oxidative Stress, and Multiple Myeloma Therapy

      • Rentian Feng, Suzanne Lentzsch
      Pages 219-231

    3. Curcumin, Oxidative Stress, and Cancer Therapy

      • Heather C. Hatcher, Frank M. Torti, Suzy V. Torti
      Pages 233-256

    4. Oxidative Stress and Pancreatic Cancer

      • Joseph J. Cullen
      Pages 257-275

    5. Oxidative Stress and Photodynamic Therapy for Prostate Cancer

      • Kevin L. Du, Jarod C. Finlay, Timothy C. Zhu, Theresa M. Busch
      Pages 277-300

    6. Oxidative Stress in Prostate Cancer

      • Weihua Shan, Weixiong Zhong, Jamie Swanlund, Terry D. Oberley
      Pages 301-331
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Keywords

About this book

During the last 30 years it has become clearly evident that oxidative stress and free radical biology play key roles in carcinogenesis, cancer progression, cancer therapy, and normal tissue damage that limits treatment efficacy during cancer therapy. These mechanistic observations have led to the realization that free radical biology and cancer biology are two integrally related fields of investigation that can greatly benefit from cross fertilization of theoretical constructs.

 

The current volume of scientific papers was assembled under the heading of Oxidative Stress in Cancer Biology and Therapy in order to stimulate the discussion of how the knowledge gained in the emerging field of oxidative stress in cancer biology can be utilized to more effectively design interventions to enhance therapeutic responses while causing fewer treatment limiting complications. The chapters contained in this volume provide highly informative emerging perspectives on how that selective enhancement of oxidative stress in cancerous tissues can be used as a target for enhancing therapeutic outcomes as well as how selective inhibition of oxidative stress could spare normal tissue damage and inhibit carcinogenesis. In this regard, the book represents an outstanding resource for both basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.

Editors and Affiliations

  • Free Radical & Radiation Biology, Graduate Program, University of Iowa, Iowa City, USA

    Douglas R. Spitz

  • Duluth Clinic, Radiation Oncology, University of Minnesota, Duluth, USA

    Kenneth J. Dornfeld

  • James H. Quillen College of Medicine, Internal Medicine, East Tennessee State University, Johnson City, USA

    Koyamangalath Krishnan

  • Radiation Oncology, Cancer Biology and Pediatrics, Vanderbilt Medical School, Nashville, USA

    David Gius

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