Handbook of Drug Interactions

1. Front Matter

   Pages i-xi

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2. Pharmacogenomics

   1. Front Matter

      Pages 1-1

      PDF

   2. Pharmacogenetics in Clinical and Forensic Toxicology: Opioid Overdoses and Deaths

      • Saeed A. Jortani, Elaine Stauble, Steven H. Wong

      Pages 3-22

3. CNS Drugs

   1. Front Matter

      Pages 23-23

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   2. Drug Interactions with Benzodiazepines: Epidemiologic Correlates with Other CNS Depressants and In Vitro Correlates with Inhibitors and Inducers of Cytochrome P450 3A4

      • David E. Moody

      Pages 25-116

   3. Antiepileptic Drugs

      • Nathan L. Kanous II, Barry E. Gidal

      Pages 117-157

   4. Opioids and Opiates

      • Seyed Adel Moallem, Kia Balali-Mood, Mahdi Balali-Mood, Mahdi Balali-Mood

      Pages 159-191

   5. Tricyclic Antidepressant Drug Interactions

      • Jeffrey P. Walterscheid, Terry J. Danielson

      Pages 193-214

   6. Selective Serotonin Reuptake Inhibitors

      • Mojdeh Mozayani

      Pages 215-227

   7. Antipsychotic Drugs and Interactions: Implications for Criminal and Civil Litigation

      • Michael Welner, Lewis Opler

      Pages 229-259

   8. Drugs of Abuse

      • Matthew P. Juhascik, Amanda J. Jenkins

      Pages 261-282

4. Cardiovascular Drugs

   1. Front Matter

      Pages 283-283

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   2. Cardiovascular Drugs

      • Uche Anadu Ndefo, Johann Auer, Ivy Poon, Goldina Ikezuagu Erowele, Angie Eaton

      Pages 285-381

5. Antibiotics

   1. Front Matter

      Pages 383-383

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   2. Antimicrobial Drugs

      • Amanda J. Jenkins, Jimmie L. Valentine

      Pages 385-411

6. Nonsteroidal Anti-inflammatory Drugs

   1. Front Matter

      Pages 413-413

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   2. Nonsteroidal Anti-inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, and Agents Used in Gout

      • Imad K. Abukhalaf, Daniel A. von Deutsch, Naser A. Ansari, Asma Alsharif

      Pages 415-475

7. Environmental and Social Pharmacology

   1. Front Matter

      Pages 477-477

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   2. Food and Drug Interactions

      • Shahla M. Wunderlich, Jacqueline Piemonte

      Pages 479-497

   3. Pharmacokinetic and Pharmacodynamic Interactions Between Alcohol and Other Drugs

      • A. Wayne Jones

      Pages 499-586

Adverse drug reactions and interactions are still a major headache for healthcare professionals around the world. The US Food and Drug Administration's database recorded almost 300,000 serious adverse events in 2009 alone, of which 45,000 instances proved fatal. This updated new edition of the indispensable guide to drug interactions incorporates fresh research completed since the book's original publication by Humana Press in 2004. Additions include a new section on pharmacogenomics, a rapidly growing field that explores the genetic basis for the variability of responses to drugs. This new material reviews important polymorphisms in drug metabolizing enzymes and applies the findings to forensic interpretation, using case studies involving opiates as exemplars.

Existing chapters from the first edition have in most cases been updated and reworked to reflect new data or incorporate better tables and diagrams, as well as to include recent drugs and formulations. Recent references have been inserted too. The handbook features extra material on illicit drug use, with a new chapter tackling the subject that covers cocaine, amphetamines and cannabis, among others. The section on the central nervous system also deals with a number of drugs that are abused illicitly, such as benzodiazepines, opiates flunitrazepam and GHB, while so-called 'social' drugs such as alcohol and nicotine are still discussed in the book's section on environmental and social pharmacology. Focusing as before on detailed explanation and incorporating both pharmacokinetic and pharmacodynamic drug interactions, this book will continue to be a lodestar for health and forensic professionals as well as students.

• Drug
• Handbook
• Interactions
• Mozayani

From the reviews of the second edition:

“This second edition outlines the most current information and highlights drugs of abuse while providing detailed information on the mechanisms of drug-drug interactions from a forensic toxicology perspective. … Any health or forensic professional could use this book to explain the underlying pharmacology of drug-drug interactions. … laboratory scientists conducting forensic analysis of drug interactions could use it to find thorough explanations of these interactions. … the book is an excellent reference for those professionals searching for underlying mechanisms of drug-drug interactions.” (Melissa M. Ranieri, Doody’s Book Reviews, March, 2012)

• Harris County Institute of Forensic Scie, Houston, USA

  Ashraf Mozayani

• Homestead, USA

  Lionel Raymon

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