Yeast Systems Biology
Methods and Protocols
Editors: Castrillo, Juan I., Oliver, Stephen G. (Eds.)
Free Preview- Presents an up-to-date view of yeast as a model eukaryote for systems biology studies
- Provides practical, easy to use methodologies
- Includes key tips and vital implementation advice from the experts
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- About this book
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Systems Biology aims at deciphering the genotype-phenotype relationships at the levels of genes, transcripts (RNAs), peptides, proteins, metabolites, and environmental factors participating in complex cellular networks in order to reveal the mechanisms and principles governing the behavior of complex biological systems. Yeast Systems Biology: Methods and Protocols presents an up-to-date view of the optimal characteristics of the yeast Saccharomyces cerevisiae as a model eukaryote, perspective on the latest experimental and computational techniques for systems biology studies, most of which were first designed for and validated in yeast, and selected examples of yeast systems biology studies and their applications in biotechnology and medicine. These experiments under controlled conditions can uncover the complexity and interplay of biological networks with their dynamics, basic principles of internal organization, and balanced orchestrated functions between organelles in direct interaction with the environment as well as the characterization of short and long-term effects of perturbations and dysregulation of networks that may illuminate the origin of complex human diseases. Written for the highly successful Methods in Molecular Biology™ series, this volume contains the kind of detailed description and implementation advice that is crucial for getting optimal results.
Practical and cutting-edge, Yeast Systems Biology: Methods and Protocols serves researchers interested in comprehensive systems biology strategies in well-defined model systems with specific objectives as well as a better knowledge of the latest post-genomic strategies at all ‘omic levels and computational approaches towards analysis, integration, and modeling of biological systems, from single-celled organisms to higher eukaryotes.
- Table of contents (28 chapters)
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Yeast Systems Biology: The Challenge of Eukaryotic Complexity
Pages 3-28
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Saccharomyces cerevisiae: Gene Annotation and Genome Variability, State of the Art Through Comparative Genomics
Pages 31-40
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Genome-Wide Measurement of Histone H3 Replacement Dynamics in Yeast
Pages 41-60
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Genome-Wide Approaches to Studying Yeast Chromatin Modifications
Pages 61-71
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Absolute and Relative Quantification of mRNA Expression (Transcript Analysis)
Pages 73-86
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Table of contents (28 chapters)
- Download Preface 1 PDF (80.5 KB)
- Download Sample pages 1 PDF (237.9 KB)
- Download Table of contents PDF (75.2 KB)
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Bibliographic Information
- Bibliographic Information
-
- Book Title
- Yeast Systems Biology
- Book Subtitle
- Methods and Protocols
- Editors
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- Juan I. Castrillo
- Stephen G. Oliver
- Series Title
- Methods in Molecular Biology
- Series Volume
- 759
- Copyright
- 2011
- Publisher
- Humana Press
- Copyright Holder
- Springer Science+Business Media, LLC
- eBook ISBN
- 978-1-61779-173-4
- DOI
- 10.1007/978-1-61779-173-4
- Hardcover ISBN
- 978-1-61779-172-7
- Softcover ISBN
- 978-1-4939-6135-1
- Series ISSN
- 1064-3745
- Edition Number
- 1
- Number of Pages
- XIV, 535
- Number of Illustrations
- 83 b/w illustrations, 2 illustrations in colour
- Topics
