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Methods in Molecular Biology

Cystic Fibrosis

Diagnosis and Protocols, Volume I: Approaches to Study and Correct CFTR Defects

Editors: Amaral, Margarida D., Kunzelmann, Karl (Eds.)

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  • Features cutting-edge protocols from the highly supportive CF scientific community
  • Contains expert tips and key implementation advice
  • Focuses on Cystic fibrosis transmembrane conductance regulator defects with an emphasis on practical approaches
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eBook $149.00
price for USA in USD (gross)
  • ISBN 978-1-61779-117-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.00
price for USA in USD
  • ISBN 978-1-61779-116-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $199.00
price for USA in USD
  • ISBN 978-1-4939-5787-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Despite the many milestones in cystic fibrosis (CF) research, progress towards curing the disease has been slow, and it is increasingly difficult to grasp and use the already wide and still growing range of diverse methods currently employed to study CF so as to understand it in its multidisciplinary nature.  Cystic Fibrosis: Diagnosis and Protocols aims to provide the CF research community and related researchers with a very wide range of high-quality experimental tools, as an easy way to grasp and use classical and novel methods applied to cystic fibrosis.  Volume I: Approaches to Study and Correct CFTR Defects focuses on the cystic fibrosis transmembrane conductance regulator (CFTR) and its expression, biogenesis, structure, and function in terms of the defects causing CF.  Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 

Comprehensive and practical, Cystic Fibrosis: Diagnosis and Protocols will provide readers with optimal working tools to address pressing questions in the best technical way, while helping all of us, as a research and clinical community, to move faster hand-in-hand toward unravelling the secrets of this challenging disorder and cure it.

Reviews

From the reviews:

“Summarize the current complex information on cystic fibrosis (CF) and the innovative new technologies available to basic scientists involved in the study of CF. … This detailed book is aimed at basic research scientists and academicians working on CF. The protocols would be of use to graduate students and postdoctoral fellows as well. … technology described would be invaluable to clinical laboratories involved in the diagnosis of CF. This represents a must-have guide for research laboratories working on the functional mechanisms of the CFTR gene.” (Luis F. Escobar, Doody’s Book Reviews, March, 2012)

Table of contents (30 chapters)

Table of contents (30 chapters)
  • Introduction to Section I: The Relevance of CF Diagnostic Tools for Measuring Restoration of CFTR Function After Therapeutic Interventions in Human Clinical Trials

    Pages 3-11

    De Boeck, Kris (et al.)

  • High-Throughput Screening of Libraries of Compounds to Identify CFTR Modulators

    Pages 13-21

    Pedemonte, Nicoletta (et al.)

  • Repair of CFTR Folding Defects with Correctors that Function as Pharmacological Chaperones

    Pages 23-37

    Loo, Tip W. (et al.)

  • Use of Primary Cultures of Human Bronchial Epithelial Cells Isolated from Cystic Fibrosis Patients for the Pre-clinical Testing of CFTR Modulators

    Pages 39-54

    Neuberger, Timothy (et al.)

  • Design of Gene Therapy Trials in CF Patients

    Pages 55-68

    Davies, Jane C. (et al.)

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-1-61779-117-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.00
price for USA in USD
  • ISBN 978-1-61779-116-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $199.00
price for USA in USD
  • ISBN 978-1-4939-5787-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cystic Fibrosis
Book Subtitle
Diagnosis and Protocols, Volume I: Approaches to Study and Correct CFTR Defects
Editors
  • Margarida D. Amaral
  • Karl Kunzelmann
Series Title
Methods in Molecular Biology
Series Volume
741
Copyright
2011
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-61779-117-8
DOI
10.1007/978-1-61779-117-8
Hardcover ISBN
978-1-61779-116-1
Softcover ISBN
978-1-4939-5787-3
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XVI, 528
Number of Illustrations
72 b/w illustrations, 4 illustrations in colour
Topics