Thyroid Cancer

1. Front Matter

   Pages i-xxvii

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2. General Considerations I

   1. Front Matter

      Pages 1-1

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   2. Anatomy and Physiology of the Thyroid Gland

      • Nikolaos Stathatos

      Pages 3-7

   3. Epidemiology of Thyroid Cancer

      • James J. Figge

      Pages 9-13

   4. Molecular Pathogenesis of Thyroid Cancer

      • James J. Figge, Nikolai A. Kartel, Dima Yarmolinsky, Gennady Ermak

      Pages 15-32

   5. Molecular Aspects of Thyroid Cancer in Children

      • Gary L. Francis

      Pages 33-39

   6. Oncogenes in Thyroid Cancer

      • Katherine B. Weber, Michael T. McDermott

      Pages 41-53

   7. Apoptosis in Thyroid Cancer

      • Su He Wang, James R. Baker Jr.

      Pages 55-61

   8. Radiation-Induced Thyroid Cancer

      • James J. Figge, Timothy Jennings, Gregory Gerasimov, Nikolai Kartel, Dima Yarmolinsky, Gennady Ermak

      Pages 63-83

   9. Classification of Thyroid Malignancies

      • Yolanda C. Oertel

      Pages 85-86

   10. Staging of Thyroid Cancer

       • Leonard Wartofsky

       Pages 87-95

   11. Thyroid Cancer in Children and Adolescents

       • Merrily Poth

       Pages 97-102

   12. Recombinant Human Thyrotropin

       • Matthew D. Ringel, Stephen J. Burgun

       Pages 103-113

3. General Considerations II

   1. Front Matter

      Pages 115-115

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   2. History of the Role of Nuclear Medicine in the Thyroid Gland and its Diseases

      • Henry N. Wagner Jr.

      Pages 117-128

   3. Prophylaxis Against Radiation Exposure from Radioiodine

      • Jacob Robbins, Arthur B. Schneider

      Pages 129-132

   4. Radioiodine Whole Body Imaging

      • Frank B. Atkins, Douglas Van Nostrand

      Pages 133-150

   5. Primer and Atlas for the Interpretation of Radioiodine Whole-Body Scintigraphy

      • Douglas Van Nostrand, Reetha Bakthula, Frank B. Atkins

      Pages 151-178

   6. False-Positive Radioiodine Scans in Thyroid Cancer

      • Brahm Shapiro, Vittoria Rufini, Ayman Jarwan, Onelio Geatti, Kimberlee J. Kearfott, Lorraine M. Fig et al.

      Pages 179-198

4. The Thyroid Nodule

   1. Front Matter

      Pages 199-199

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are new to this edition. The authors provide not only the The second edition of Thyroid Cancer: A Comp- most current review of their respective areas, but also their hensive Guide to Clinical Management marks the pub- own recommendations and approach. The reader is fo- cation of a markedly updated and expanded volume that warned that in many cases these approaches, albeit rooted covers all aspects of the etiology, pathogenesis, diag- sis, initial treatment, and long-term management of all in available data, may be empiric rather than based varieties of thyroid cancer. Like the first edition, it will upon clear-cut results of well-controlled clinical t- als. Nevertheless, controversial issues are examined serve as a valuable reference source for pathologists, and evidence-based recommendations are presented endocrine surgeons, endocrinologists, nuclear medicine when available. physicians, and oncologists. However, the biggest There are updated chapters on our current state change is that the second edition is significantly enlarged and expanded to encompass important and extensive of knowledge of the molecular changes in thyroid treatments of more topics related to nuclear medicine. cancer, molecular markers, and how targeted the- pies are being developed. New therapeutic trials of Nuclear medicine physicians and procedures play a key redifferentiation agents to restore the sodium iodide role in the management of thyroid cancer patients and in symporter when lacking and more traditional che- retrospect, a comprehensive discussion of topics related therapies are discussed, with referral sources listed for to that field was somewhat lacking in the first edition.

• Staging
• apoptosis
• carcinoma
• classification
• diagnosis
• imaging
• positron emission tomography
• surgery
• ultrasound

From the reviews

"...our present state of knowledge provides clinicians a wide variety of diagnostic and therapeutic modalities to effectively manage this group of cancers. I believe the knowledge contained in this text will give the practicing clinician the necessary information to provide patients the latest and best therapeutic techniques."-Foreword by Ernest L. Mazzaferri, MD

"This is an excellent comprehensive up-to-date text that is scholarly and complete, yet thoroughly readable. It provides guidance to clinicians and others interested in thyroid cancer based on a combination of a distillate of the published literature [which is fully documented] and the personal experience of the expert author of each chapter. . .the text reads quickly. . . I recommend this text to anyone interested in an up-to-date, detailed, clinical guideline to the management of patients with thyroid cancer and the clinical science behind the recommendation."-Journal of Nuclear Medicine

"This book illustrates the importance of the multidisciplinary approach available in major medical centers for the care of patients with thyroid cancer. The wide-ranging topical nature of this book will interest those working in many fields of medicine. It should be essential reading for trainees in endocrinology, pathology, imaging, nuclear medicine, surgery, and oncology, as well as for specialists in those fields."-The New England Journal of Medicine

"The book is truly unique and is a critical addition to the contemporary endocrine texts held by general physicians, surgeons, and endocrinologists alike. The book is designed to be a comprehensive guide for clinical management of thyroid cancer and in this regard, is an overwhelming success...One of the most important aspects of this text is the multidisciplinary emphasis provided to all the sub specialists who attend patients with thyroid neoplasms... The book is uniquely organized with several chapters exclusively devoted to the surgical and medical management of individual types of thyroid cancer. This organization is important, because it helps emphasize that each thyroid cancer is unique and not necessarily amenable to one standardized form of treatment...A parallel emphasis of the book is the reliance on evidence-based practice...each chapter is thoroughly referenced, making it easy for the reader to ascertain the original studies on which these conclusions and controversy are based....One of the strengths of this book is the devotion of separate chapters to the management of unique thyroid cancers and unique patients...The text is right up -to- date with regards to the molecular biology of thyroid cancers, the management of medullary thyroid carcinoma, the use of alternative imaging techniques and the use of rhTSH for scanning patients with a history of thyroid cancer...To conclude, this is a unique and important text for all practitioners caring for patients with thyroid cancer. I congratulate the Editor and Authors for their success in detailing this complex and rapidly changing field." ------Trends in Endocrinology and Metabolism

"...recommended for anyone who would like a comprehensive reference on the practical aspects of thyroid cancer management." - Head & Neck

"This comprehensive book brings an instructive review of present knowledge on the pathology, etiology, epidemiology, diagnostic methods and the methods of surgical, radioiodine and chemotherapeutic treatment of various forms of thyroid cancer. Written by outstanding experts and professionally edited by Leonard Wartofsky, it may be considered of substantial utility to all physicians dealing with thyroid diseases." - Endocrine Regulations

From the reviews of the second edition:

"An excellent, truly comprehensive book that covers the etiology, pathogenesis, and clinical management of all forms of thyroid cancer. … While the book is written clearly enough to be accessibleto physicians in training, it will probably be most useful for practicing physicians. The targeted readers include endocrinologists, endocrine surgeons, nuclear medicine specialists, pathologists, and oncologists. … This is an outstanding textbook … . surely a work to be added to the library of every clinician taking care of patients with thyroid cancer." (Brian W. Kim, Doody’s Review Service, May, 2006)

"This book includes almost twice as many chapters and contributors as the first edition. I especially enjoyed the addition of patient-focused content, including lists of useful books and Web sites and practical advice regarding radioiodine treatment … . an excellent, up-to-date book that is of practical value across all specialties involved in the management of thyroid cancer. It also provides a scholarly overview of the evidence base." (Jayne Franklyn, The New England Journal of Medicine, July, 2006)

"This is the second edition of an outstanding textbook edited by Leonard Wartofsky and Douglas Van Nostrand. The editors are to be congratulated on bringing together a remarkable array of multidisciplinary authors, who cover every topic pertaining to the clinical management of thyroid cancer. … Overall, I would highly recommend this book to all practitioners and associated specialties involved in the management of thyroid cancer. The book is clearly and concisely written, well illustrated … . an excellent textbook." (John Watkinson, Annals of the Royal College of Surgeons of England, Vol. 90, June, 2008)

• Washington Hospital Center, Washington, DC

  Leonard Wartofsky, Douglas Nostrand

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