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  • Book
  • © 2011

Studies on Experimental Models

  • There is no such book exists on the market
  • Important handbook for oxidative stress researchers to drug development scientists to test the efficacy of various drugs, antioxidants, radical scavengers or dietary components and food
  • Contains different experimental models of medical research by leading scientists in this area
  • Includes supplementary material: sn.pub/extras

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Softcover Book USD 329.99
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Hardcover Book USD 219.99
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Table of contents (33 chapters)

  1. Front Matter

    Pages i-xix
  2. Diabetes

    1. Front Matter

      Pages 1-1
    2. Experimental Models of Oxidative Stress Related to Cardiovascular Diseases and Diabetes

      • Maria D. Mesa, Concepcion M. Aguilera, Angel Gil
      Pages 39-60
  3. Cardiovascular

    1. Front Matter

      Pages 61-61
    2. Small Heat Shock Proteins and Doxorubicin-Induced Oxidative Stress in the Heart

      • Karthikeyan Krishnamurthy, Ragu Kanagasabai, Lawrence J. Druhan, Govindasamy Ilangovan
      Pages 105-130
    3. In vivo Imaging of Antioxidant Effects on NF-κB Activity in Reporter Mice

      • Ingvild Paur, Harald Carlsen, Rune Blomhoff
      Pages 157-184
  4. Neurology

    1. Front Matter

      Pages 185-185
    2. MPTP and Oxidative Stress: It’s Complicated!

      • V. Jackson-Lewis, M. A. Tocilescu, R. DeVries, D. M. Alessi, S. Przedborski
      Pages 187-209
    3. Oxidative Stress in Alzheimer’s Disease: A Critical Appraisal of the Causes and the Consequences

      • Jaewon Chang, Sandra Siedlak, Paula Moreira, Akihiko Nunomura, Rudy J. Castellani, Mark A. Smith et al.
      Pages 211-220
    4. Stress Gene Deregulation in Alzheimer Peripheral Blood Mononuclear Cells

      • Olivier C. Maes, Howard M. Chertkow, Eugenia Wang, Hyman M. Schipper
      Pages 251-263
  5. Ocular Diseases

    1. Front Matter

      Pages 301-301
    2. Neovascular Models of the Rabbit Eye Induced By Hydroperoxide

      • Toshihiko Ueda, Takako Nakanishi, Kazushi Tamai, Shinichi Iwai, Donald Armstrong
      Pages 303-317

About this book

There is a widespread consensus that use of antioxidants as a therapeutic approach may counteract free radical mediated pathologies. However, the role of antioxidants in normal physiology and redox signaling is still in its infancy. Since oxidative stress is related to various diseases and pathologies, scientists are eager to study the disease in humans, but it is not always ethical to study all the aspects of the disease in humans. Thus, it becomes mandatory to study the disease process and the mechanisms behind it through experimental models which generally involve animals, in vitro/cell culture studies, primates and even humans to a certain extent. Studies on Experimental Models contains data on the experimental models or review of such models of oxidative stress in various diseases. It is structured into six sections, which are as follows: diabetes, cardiovascular, neurology, ocular diseases, toxicology/environmental and in vitro/tissue culture. Each section presents a sketch of models in humans, animals and in vitro methods. Taken together, they comprise a valuable reference for basic and clinical scientists, one aimed at contributing to the advancement of oxidative stress research using appropriate animal models.

Reviews

From the reviews:

“It is intended to contribute to the advancement of oxidative stress research using appropriate animal models and to serve as a valuable reference for basic and clinical scientists. … students, basic scientists, clinical scientists, and physicians interested in understanding more about oxidative stress will find this book extremely useful. … This book provides comprehensive coverage of studies on experimental models related to oxidative stress involved in various diseases, particularly diabetes, cardiovascular, neurological, and ocular diseases.” (Omer Iqbal, Doody’s Book Reviews, October, 2011)

Editors and Affiliations

  • Dept. Health & Caring Sciences, University Uppsala, Uppsala, Sweden

    Samar Basu

  • Dept. Surgical Sciences, Anaesthesiology, & Intensive Care, Uppsala University Hospital, Uppsala, Sweden

    Lars Wiklund

Bibliographic Information

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access