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Neuromethods

Animal Models of Dementia

Editors: De Deyn, Peter Paul, Van Dam, Debby (Eds.)

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  • Appeals to a broad readership from neuropathologists, pharmacists, biochemists, and biologists to clinical neurologists
  • Features a large, comprehensive section on Alzheimer’s disease
  • Includes contributions from prominent investigators sharing their experience through detailed, easily accessible methods
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eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-60761-898-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-1-60761-897-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-1-4939-6118-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity. Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer’s disease, Parkinson’s disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models. Comprehensive and efficient, Animal Models of Dementia will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research.

Reviews

From the book reviews:

“A complete guide to lesion induced, genetic knockout, and phylogenetic approaches to dementias is catalogued. … I recommend this book for animal researcher for sure, and neurologists in particular.” (Joseph J. Grenier, Amazon.com, August, 2014)

“A great add-on to more basic textbooks on mechanisms of dementia. The book not only nicely summarizes ongoing efforts to model dementia but also describes how to investigate underlying mechanisms at various level of complexity. … Importantly, leading mouse models are discussed, which is very useful for newcomers to the field, as there are a lot of different models. … Additionally, the book provides information about ethics on animal experimentation and information on intellectual property, issues that can be rarely found in textbooks.” (Karl Peter Giese, British Journal of Clinical Pharmacology, May, 2011)

Table of contents (34 chapters)

Table of contents (34 chapters)
  • General Introduction to Animal Models of Human Conditions

    Pages 3-13

    Deyn, Peter Paul (et al.)

  • Animal Models of Dementia: Ethical Considerations

    Pages 15-33

    Olsson, I. Anna S. (et al.)

  • The Role of Rodent Models in the Drug Discovery Pipeline for Dementia

    Pages 35-49

    Dam, Debby (et al.)

  • Species, Strain, and Gender Issues in the Development and Validation of Animal Models of Dementia

    Pages 53-75

    Dijck, Annemie (et al.)

  • Transgenic and Gene Targeted Models of Dementia

    Pages 77-90

    Conlon, Ronald A.

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-60761-898-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-1-60761-897-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-1-4939-6118-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Animal Models of Dementia
Editors
  • Peter Paul De Deyn
  • Debby Van Dam
Series Title
Neuromethods
Series Volume
48
Copyright
2011
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-60761-898-0
DOI
10.1007/978-1-60761-898-0
Hardcover ISBN
978-1-60761-897-3
Softcover ISBN
978-1-4939-6118-4
Series ISSN
0893-2336
Edition Number
1
Number of Pages
XV, 732
Topics