Stem Cells in the Respiratory System

1. Front Matter

   Pages i-x

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2. Stem and Progenitor Cells of the Airway Epithelium

   • Susan D. Reynolds, Moumita Ghosh, Heather M. Brechbuhl, Shama Ahmad, Carl W. White

   Pages 1-23

3. Mesenchymal Stem Cells for Lung Repair and Regeneration

   • Daniel J. Weiss

   Pages 25-42

4. The Role of Progenitor Cells in Lung Disease Prognosis

   • Ellen L. Burnham, Susan Majka, Marc Moss

   Pages 43-62

5. The Role of Fibrocytes in Lung Repair and Fibrosis

   • Ellen C. Keeley, Borna Mehrad, Robert M. Strieter

   Pages 63-76

6. Stem Cells and Cell–Matrix Interactions in Lung

   • Viranuj Sueblinvong, Jesse Roman

   Pages 77-96

7. Mobilization of Stem Cells/Progenitor Cells by Physical Activity

   • Patrick Wahl, Wilhelm Bloch

   Pages 97-119

8. Mesenchymal Stem Cells for Acute Lung Injury

   • Jae W. Lee, Naveen Gupta, Michael A. Matthay

   Pages 121-140

9. Animal Models of Lung Injury: Role for Mesenchymal Stem Cells

   • Mauricio Rojas, Smita Iyer, Carter Co, Kenneth L. Brigham

   Pages 141-158

10. Back Matter

    Pages 159-168

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In this state-of-the-art exploration of a hugely dynamic and fast-evolving field of research, leading researchers share their collective wisdom on the role that stem cells could play in the context of physiological stress and lung injury. The text focuses on reviewing the most relevant—and recent—ideas on using local, endogenous, and exogenous progenitor/stem cells in preventing and treating injury to the lung. The lungs are one of the most complex organs in the human body, with a mature adult lung boasting at least 40 morphologically differentiated cell lineages. Our entire blood supply passes through the lung’s alveolar units during oxygenation. This interaction with the outside world, along with the intricacies of its structure, makes the lung a highly susceptible organ that is vulnerable to numerous types of injury and infection. This means that the mechanisms of lung repair are in themselves correspondingly complex. Because of their multipotentiality, as well as the fact of the lung’s relatively rapid cell turnover, stem cells are thought to be an important alternative cell-base therapy in lung injury. Despite the controversial nature of stem cell research, there has been growing interest in both local and endogenous stem cells in the lung. This highly topical book with chapters on everything from using mesenchymal stem cells in lung repair to the effect of physical activity on the mobilization of stem and progenitor cells, represents an exciting body of work by outstanding investigators and will be required reading for those with an interest in the subject.

• cell
• infection
• regeneration
• stem cell
• stem cells
• stem cells, lungs, pulmonary

From the reviews:

“This basic science book includes eight chapters on topics ranging from stem cell-matrix interactions to animal models of lung disease. … This concise book is written for basic science and clinical researchers interested in adult stem cells and pulmonary pathophysiology. … the information presented is valuable and informative, particularly if you are keen to learn more about the immunomodulatory functions of bone marrow stem cells.” (Bruce A. Fenderson, Doody’s Review Service, December, 2010)

“In this book, a number of leading investigators review the varied responses of different stem cell populations following physiological stress and lung injury. … The book is aimed at researchers and will be invaluable for graduate students or established scientists to dip into as required. Each chapter is well written, logical and serves as a stand alone review … . I enjoyed this book. The authors should be congratulated for producing an excellent book that reviews a difficult, fast moving and controversial area of biology.” (British Journal of Clinical Pharmacology, May, 2011)

• Dept. Medicine, Div. Pulmonary, Allergy & Critical, Emory University, Atlanta, USA

  Mauricio Rojas

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