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Methods in Molecular Biology

Mass Spectrometry Imaging

Principles and Protocols

Editors: Rubakhin, Stanislav S., Sweedler, Jonathan V. (Eds.)

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  • -Illustrates mass spectrometry imaging on the sub-cellular, cellular, tissue, and whole body levels
  • -Presents comprehensive information on sample preparation, data acquisition, and data processing approaches for use in bioanalytical mass spectrometry and mass spectrometry imaging
  • -Includes a wide range of examples on the use of state-of-the-art mass spectrometric instrumentation
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eBook $129.00
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  • ISBN 978-1-60761-746-4
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Hardcover $169.99
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Softcover $169.99
price for USA in USD
About this book

Mass spectrometry (MS) offers unmatched capabilities for the detection, characterization, and identification of a broad range of analytes. Mass spectrometry imaging (MSI) integrates MS data with information on the spatial distributions of the analytes, further enhancing the applicability of MS. In Mass Spectrometry Imaging: Principles and Protocols, expert practitioners from academia, industry, and the clinic contribute cutting-edge protocols describing the application of MSI to investigations of analyte localization in a variety of specimens, from microorganisms to plant and animal tissues. Divided into three sections, this volume presents the principles of MS, current and future trends of MSI, and qualitative and quantitative protocols to measure and identify endogenous metabolites and xenobiotics. An array of MSI approaches and technologies for characterizing peptide and protein distributions are described in detail. Written in the highly successful Methods in Molecular Biology™ series format, protocol chapters include introductions to their respective topics, lists of the necessary materials and reagents, and step-by-step, readily reproducible laboratory procedures. Also included are notes providing tips to avoid experimental pitfalls and helpful suggestions for method troubleshooting. Comprehensive and up-to-date, Mass Spectrometry Imaging: Principles and Protocols is written for scientists, biological and chemical engineers, and clinicians who are interested in applying MSI in their work and those who would benefit from having detailed experimental guidelines available in a single, convenient source.

Reviews

From the reviews:

“The book aims to provide comprehensive background information on mass spectrometry imaging (MSI) technology … . a monograph that has the merit of summarizing many protocols of great value for all scientists, engineers, and clinicians who are interested in applying MSI in their work. The book is clearly written and comprehensive, and has a good balance between theoretical descriptions and broad practical descriptions. Both established MSI researchers and those new to the field would benefit from this valuable source of methodological information.” (José Manuel Costa-Fernández, Analytical and Bioanalytical Chemistry, Vol. 401, 2011)

Table of contents (27 chapters)

Table of contents (27 chapters)
  • Imaging Mass Spectrometry: Viewing the Future

    Pages 3-19

    Schwartz, Sarah A. (et al.)

  • A Mass Spectrometry Primer for Mass Spectrometry Imaging

    Pages 21-49

    Rubakhin, Stanislav S. (et al.)

  • Imaging of Metals, Metalloids, and Non-metals by Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) in Biological Tissues

    Pages 51-82

    Becker, J. Sabine (et al.)

  • Lipid Detection, Identification, and Imaging Single Cells with SIMS

    Pages 85-97

    Heien, Michael L. (et al.)

  • The Application and Potential of Ion Mobility Mass Spectrometry in Imaging MS with a Focus on Lipids

    Pages 99-111

    Woods, Amina S. (et al.)

Buy this book

eBook $129.00
price for USA in USD
  • ISBN 978-1-60761-746-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
Softcover $169.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Mass Spectrometry Imaging
Book Subtitle
Principles and Protocols
Editors
  • Stanislav S. Rubakhin
  • Jonathan V. Sweedler
Series Title
Methods in Molecular Biology
Series Volume
656
Copyright
2010
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-60761-746-4
DOI
10.1007/978-1-60761-746-4
Hardcover ISBN
978-1-60761-745-7
Softcover ISBN
978-1-61779-696-8
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XIV, 490
Topics