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Methods in Molecular Biology

RNA Interference

From Biology to Clinical Applications

Editors: Min, Wei-Ping, Ichim, Thomas (Eds.)

  • -Provides a global overview of the state-of-the-art in RNA interference and practical details used experimentally in modern day experiments
  • -Deciphers, organizes, and explains the myriad of techniques used in gene silencing research
  • -Stimulates new experimental possibilities by gathering approaches that generally would not be present in the same volume
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Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-1-60761-588-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-1-60761-587-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-1-4939-6134-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

From the early days when RNA interference was a strange artifact in worms to the 2006 Noble Prize received by Fire and Mello and the current clinical trials, the field of RNA interference has grown at a breakneck pace. In RNA Interference: From Biology to Clinical Applications, expert contributors provide an overview of the most current science and protocols that span the biological disciplines from detailed nucleic acid chemistry, to pharmacology, to the manipulation of signal transduction pathways. Divided into three distinct sections, this volume delves into the physiology of RNA interference, RNA interference in the laboratory and siRNA delivery, and preclinical and clinical issues associated with the use of RNAi-inducing agents as drugs in order to stimulate new questions and offer the tools necessary to start addressing those questions. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and inspiring, RNA Interference: From Biology to Clinical Applications aims to promote and motivate innovation by reviewing what has been done, providing details of how it has been done, and encouraging speculation on what the future may hold.

Reviews

From the reviews:

“The book provides a broad overview of RNA chemistry, the pharmacology and the manipulation of signaling pathways by using RNA interference. … This book is very well written and will be an asset to any researcher who uses RNA interference as a tool to study gene function. … and will probably mainly be of use to researcher already working in the field and familiar with different techniques of siRNA delivery.” (Anna Vossenkaemper, Immunology News, November, 2010)

Table of contents (27 chapters)

  • Endogenous Antiviral Mechanisms of RNA Interference: A Comparative Biology Perspective

    Sidahmed, Abubaker M. E. (et al.)

    Pages 3-19

  • Monitoring Innate Immune Recruitment by siRNAs in Mammalian Cells

    Gantier, Michael P. (et al.)

    Pages 21-33

  • Current Knowledge of MicroRNAs and Noncoding RNAs in Virus-Infected Cells

    Ouellet, Dominique L. (et al.)

    Pages 35-65

  • Allele-Specific Silencing by RNA Interference

    Hohjoh, Hirohiko

    Pages 67-79

  • Computational siRNA Design Considering Alternative Splicing

    Kim, Young J.

    Pages 81-92

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-1-60761-588-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-1-60761-587-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-1-4939-6134-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
RNA Interference
Book Subtitle
From Biology to Clinical Applications
Editors
  • Wei-Ping Min
  • Thomas Ichim
Series Title
Methods in Molecular Biology
Series Volume
623
Copyright
2010
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-60761-588-0
DOI
10.1007/978-1-60761-588-0
Hardcover ISBN
978-1-60761-587-3
Softcover ISBN
978-1-4939-6134-4
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XVI, 450
Topics