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Neuromethods

Transgenic and Mutant Tools to Model Brain Disorders

Editors: Kalueff, Allan V., Bergner, Carisa L. (Eds.)

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  • Provides an accessible reference volume for animal models in behavioral neuroscience research
  • Details the process of turning a biological observation into a high-throughput screen
  • Covers a wide range of species from zebra fish to rats
  • Addresses a broad spectrum of brain disorders, from anxiety to schizophrenia
  • Presents a modular approach to experimental modeling of brain disorders
  • Comprehensive guide to translational biopsychiatry research focusing on genetic factors in brain disorders
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eBook $129.00
price for USA in USD (gross)
  • ISBN 978-1-60761-474-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-1-60761-473-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA in USD
  • ISBN 978-1-4939-6145-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

As the presence of genetically modified animal models in research laboratories has multiplied, the role of genetic factors in the pathogenesis of brain disorders has become particularly important. The refinement of molecular genetic methods has continued to broaden our understanding of the genetic factors associated with a variety of disorders.  In Transgenic and Mutant Tools to Model Brain Disorders, leading scientists specializing in this field contribute a timely collection of recent advances featuring a vast array of topics in order to contribute to the diverse approaches taken toward the evaluation of genetically modified models in biomedical research.  Opening with several chapters covering general aspects of genetically modified animal models, the book then continues with detailed chapters on models of specific human brain disorders, including OCD, Rett Syndrome, anxiety disorders, depression, and schizophrenia.  As a volume in the successful Neuromethods™ series, the chapters provide authoritative reviews covering the most commonly used approaches in the field.

Cutting-edge and concise, Transgenic and Mutant Tools to Model Brain Disorders offers a comprehensive and descriptive overview on a variety of topics in neuroscience and biological psychiatry.

Reviews

From the reviews:

“This is an exceptionally interesting new book on the use of animal models, specifically transgenic and mutant models, in the understanding of brain disorders. … Written and edited by internationally recognized experts in the field, this is a welcome introduction to this subject. … They target scientists ‘from all backgrounds and levels of experience.’ … an excellent book on an important area of study in gene-brain-behavior relationships. Researchers in this field would benefit from reading this interesting book.” (Michael Joel Schrift, Doody’s Review Service, August, 2010)

Table of contents (12 chapters)

Table of contents (12 chapters)
  • Mutant and Transgenic Zebrafish in Modeling Neurobehavioral Disorders

    Pages 3-12

    Bergner, Carisa L. (et al.)

  • Knockout and Mutant Rats

    Pages 13-31

    Müller, Mareike (et al.)

  • Rat Mutants with Lateralized Rotational Behavior for Studying Disturbances in Cerebral Asymmetries and Their Involvement in Brain Disorders

    Pages 33-64

    Löscher, Wolfgang

  • GABAA Receptor α1 Subunit (Gabra1) Knockout Mice: Review and New Results

    Pages 65-90

    Ye, Gui-Lan (et al.)

  • Basal Ganglia Disorders in Genetic Models and Experimentally Induced Lesions

    Pages 91-112

    Lalonde, Robert (et al.)

Buy this book

eBook $129.00
price for USA in USD (gross)
  • ISBN 978-1-60761-474-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-1-60761-473-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA in USD
  • ISBN 978-1-4939-6145-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Transgenic and Mutant Tools to Model Brain Disorders
Editors
  • Allan V. Kalueff
  • Carisa L. Bergner
Series Title
Neuromethods
Series Volume
44
Copyright
2010
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-60761-474-6
DOI
10.1007/978-1-60761-474-6
Hardcover ISBN
978-1-60761-473-9
Softcover ISBN
978-1-4939-6145-0
Series ISSN
0893-2336
Edition Number
1
Number of Pages
XIV, 246
Topics