Mammalian Brain Development

1. Front Matter

   Pages i-xiv

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2. Sexual Differentiation of the Brain: Genetic, Hormonal and Trophic Factors

   • Hugo F. Carrer, María J. Cambiasso

   Pages 1-15

3. Life at the Interface Between a Dynamic Environment and a Fixed Genome: Epigenetic Programming of Stress Responses by Maternal Behavior

   • Ian C. G. Weaver

   Pages 17-39

4. Effects of Early Life Seizures and Anti-epileptic Drug Treatment on Human Brain Development in Human Models

   • Eric D. Marsh, Amy R. Brooks-Kayal

   Pages 41-52

5. Prenatal Development of the Human Blood-Brain Barrier

   • Luca Cucullo

   Pages 53-75

6. Seizure Propensity and Brain Development: A Lesson from Animal Models

   • Jana Velíšková, Annamaria Vezzani, Astrid Nehlig

   Pages 77-104

7. Seizures and Antiepileptic Drugs: Does Exposure Alter Normal Brain Development in Animal Models?

   • Aristea S. Galanopoulou, Libor Velíšek, Solomon L. Moshé

   Pages 105-132

8. Overview of Neural Mechanisms in Developmental Disorders

   • Ayush Batra, Erin Carlton, Kathleen Franco

   Pages 133-151

9. Drug Permeation Across the Fetal Maternal Barrier

   • Chaitali Ghosh, Nicola Marchi

   Pages 153-170

10. In Vivo Imaging of Brain Development: Technologies, Models, Applications, and Impact on Understanding the Etiology of Mental Retardation

    • Vicko Gluncic

    Pages 171-192

11. Congenital, Non-inheritable Chromosomal Abnormalities Responsible for Neurological Disorders

    • Riccardo Bianchi, Patrizia D’Adamo

    Pages 193-218

12. Erratum

    • Humana Press, a part of Springer Science+Business Media, LLC

    Pages 228-228

13. Back Matter

    Pages 219-227

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Denis Noble Nearly a decade after completion of the first draft of the entire Human Genome sequence we are in a better position to assess the nature and the consequences of that heroic achievement, which can be seen as the culmination of the molecular biological revolution of the second half of the twentieth century. The achievement itself was celebrated at the highest levels (President and Prime Minister) on both sides of the Atlantic, and rightly so. DNA sequencing has become sufficiently c- mon now, even to the extent of being used in law courts, that it is easy to forget how technically difficult it was and how cleverly the sequencing teams solved those problems in the exciting race to finish by the turn of the century [1, 2]. The fanfares were misplaced, however, in an important respect. The metaphors used to describe the project and its biological significance gave the impression to the public at large, and to many scientists themselves, that this sequence would reveal the secrets of life. DNA had already been likened to a computer program [3]. The “genetic program” for life was therefore to be found in those sequences: A kind of map that had simply to be unfolded during development. The even more colo- ful “book of life” metaphor gave the promise that reading that book would lead to a veritable outpouring of new cures for diseases, hundreds of new drug targets, and a brave new world of medicine.

• Brain
• Brain damage
• Brain development
• Chromosom
• Genetics
• Mammalian brain
• Neurodegeneration
• Neurodevelopmental
• Neurogenetics
• Neurological disorders
• Prenatal brain
• behavior
• neural mechanisms

• Div. Cerebrovascular Research, Cleveland Clinic Foundation, Cleveland, U.S.A.

  Damir Janigro

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