Methods in Molecular Biology

Ligand-Macromolecular Interactions in Drug Discovery

Methods and Protocols

Editors: Roque, Ana Cecília A. (Ed.)

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  • Provides an easily accessible reference volume for the study of ligand-macromolecule interactions in the context of drug research written by leading researchers in the field
  • Details the principles of molecular recognition
  • Covers a wide range of techniques and assays for the design and screening of chemical and biological microarrays and libraries
  • Comprehensive guide to developing, running, and analyzing ligand-macromolecule assays in high-throughput screening formats
  • Readily reproducible techniques for key experiments in the search and analysis of bioactive compounds
  • Step-by-step laboratory instructions that ensure successful results
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eBook $129.00
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  • ISBN 978-1-60761-244-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase Institutional customers should get in touch with their account manager
Hardcover $169.99
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Softcover $169.99
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About this book

Drug research has been greatly transformed by the "omics revolution" and advances in computational tools, combinatorial chemistry, and high throughput screening techniques (HTS). These implements have advanced the ability to identify target molecules that serve as points of attack for future medicines, the design and synthesis of potential lead compounds, and further characterization, screening, and assays for therapeutic efficacy and toxicity. In Ligand-Macromolecular Interactions in Drug Discovery: Methods and Protocols, experts in the field highlight the main principles and methodologies currently utilized in the study of molecular interactions between compounds, either natural or synthetic, and complementary biological targets, within the scope of drug discovery. Beginning with a historical perspective of drug research focusing on the contribution of genomics, proteomics, high-throughput methods, and computational developments in drug discovery, the book then delves into highly detailed methods on topics such as NMR spectroscopy, compound library design and synthesis, chemical and biological microarrays, and many others.  Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.


Authoritative and cutting-edge, Ligand-Macromolecular Interactions in Drug Discovery: Methods and Protocols will serve as an ideal guide to scientists in academia and in industry who are striving to further our knowledge of medicines.

Table of contents (18 chapters)

Table of contents (18 chapters)

Buy this book

eBook $129.00
price for USA in USD
  • ISBN 978-1-60761-244-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase Institutional customers should get in touch with their account manager
Hardcover $169.99
price for USA in USD
Softcover $169.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Ligand-Macromolecular Interactions in Drug Discovery
Book Subtitle
Methods and Protocols
Editors
  • Ana Cecília A. Roque
Series Title
Methods in Molecular Biology
Series Volume
572
Copyright
2010
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-60761-244-5
DOI
10.1007/978-1-60761-244-5
Hardcover ISBN
978-1-60761-243-8
Softcover ISBN
978-1-4939-6177-1
Series ISSN
1064-3745
Edition Number
1
Number of Pages
X, 297
Topics