Cancer Drug Discovery and Development

Checkpoint Controls and Targets in Cancer Therapy

Editors: Siddik, Zahid H. (Ed.)

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  • Brings together experts, who are defining the field of checkpoints
  • Represents a unique collection of insightful contributions that will serve as an important resource for both the research community and the medical oncologists
  • Since checkpoint regulation is critical in understanding cancer development and cancer therapy, the interest will be diverse and will appeal to both basic and translational investigators alike
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eBook $169.00
price for USA in USD
  • ISBN 978-1-60761-178-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-1-60761-177-6
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $219.99
price for USA in USD
  • ISBN 978-1-61779-635-7
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
About this book

 

There is no question that loss of cell cycle checkpoint regulation is an intrinsic characteristic of cancer. However, many tumors retain parallel checkpoint pathways that are activated by antitumor agents and facilitate therapeutic response. Failures in these therapy-linked checkpoint controls are closely associated with cancers that are highly resistant to therapeutic interventions. Checkpoint Controls and Targets in Cancer provides present-day mechanistic understandings of how multiple sets of proteins orchestrate cell cycle progression, discusses critical checkpoint controls that are evaded for cancer development, focuses on checkpoint pathways associated with antitumor effects, and identifies specific checkpoint regulators for targeting with small molecules in the clinical management of cancer. These aspects of cell cycle checkpoints are articulated critically by renowned experts from both academia and industry, and new concepts are forwarded that challenge existing dogmas. Collectively, Checkpoint Controls and Targets in Cancer provides a unique collection of insightful contributions, which are timely and offer significant interest and appeal to basic, translational and clinical scientists.

Reviews

From the reviews: “This nicely organized book focuses on cell cycle checkpoint and cancer biology/therapeutics. … The book is written for graduate students, residents, and postdoctoral investigators in basic, translational, or clinical cancer research. The contributing authors are active investigators at the forefront of this field. … This book presents timely, comprehensive reviews of the rapidly progressing field of checkpoint. It should be quite useful for readers who are seeking a solid grasp of updated information in this field.” (Hiroaki Kiyokawa, Doody’s Review Service, March, 2010)

Table of contents (17 chapters)

Table of contents (17 chapters)

Buy this book

eBook $169.00
price for USA in USD
  • ISBN 978-1-60761-178-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-1-60761-177-6
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $219.99
price for USA in USD
  • ISBN 978-1-61779-635-7
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Checkpoint Controls and Targets in Cancer Therapy
Editors
  • Zahid H. Siddik
Series Title
Cancer Drug Discovery and Development
Copyright
2009
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-60761-178-3
DOI
10.1007/978-1-60761-178-3
Hardcover ISBN
978-1-60761-177-6
Softcover ISBN
978-1-61779-635-7
Series ISSN
2196-9906
Edition Number
1
Number of Pages
XIV, 274
Number of Illustrations
30 b/w illustrations, 13 illustrations in colour
Topics