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Methods in Molecular Biology

Drug-DNA Interaction Protocols

Editors: Fox, Keith (Ed.)

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  • Fully updated from the first edition to include up-to-date methods for studying drug-DNA interactions
  • Written by experts with hands-on experience of the techniques
  • Combines a wide range of approaches for analyzing drug-DNA interactions, from the cellular to the structural
  • Includes a collection of useful molecular techniques for exploring the interaction between ligands and DNA
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eBook $139.00
price for USA in USD
  • ISBN 978-1-60327-418-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase Institutional customers should get in touch with their account manager
Hardcover $179.99
price for USA in USD
Softcover $179.99
price for USA in USD
About this book

The last few years have witnessed the creation of new generations of sequence reading compounds, which have incredible potential for targeting specific DNA sequences. In Drug-DNA Interaction Protocols, Second Edition, expert researchers explore these compounds, revealing how a deeper understanding of the structure of DNA, along with an improved ability to manipulate it, has led to much progress in recent years. Chapters describe a new arsenal of techniques for probing the interactions between drugs and DNA, including various biophysical techniques for quantifying these interactions and for describing them in molecular and atomic detail, and they comprehensively consider both molecular and cellular approaches. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.

 Authoritative and current, Drug-DNA Interaction Protocols, Second Edition, is a critical volume that includes a wide range of chapters, which together provide methods for assessing the strength and mode of binding, the sequence selectivity, and the effect on biological systems.

Reviews

From the reviews of the second edition:

“Provides authoritative and current information on the binding of new generations of DNA sequence reading compounds … . The intended audience includes postgraduates, postdoctoral workers, and established scientists … . even clinical investigators such as oncologists may find this book quite useful. … This well-illustrated book of chapters written by leading experts will be extremely useful for postgraduates, post-doctoral fellows, established scientists, and some clinicians interested in the field of drug-DNA interactions. … this update will be welcomed by students and justifies replacement.” (Omer Iqbal, Doody’s Review Service, May, 2010)

Table of contents (19 chapters)

Table of contents (19 chapters)
  • Quantitative Analysis of Small Molecule–Nucleic Acid Interactions with a Biosensor Surface and Surface Plasmon Resonance Detection

    Pages 1-23

    Liu, Yang (et al.)

  • Thermal Melting Studies of Ligand DNA Interactions

    Pages 25-35

    Guédin, Aurore (et al.)

  • Circular and Linear Dichroism of Drug-DNA Systems

    Pages 37-54

    Rodger, Alison

  • Drug Binding to DNA⋅RNA Hybrid Structures

    Pages 55-70

    Wheelhouse, Richard T. (et al.)

  • Quantification of Binding Data Using Capillary Electrophoresis

    Pages 71-88

    Araya, Fitsumbirhan (et al.)

Buy this book

eBook $139.00
price for USA in USD
  • ISBN 978-1-60327-418-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase Institutional customers should get in touch with their account manager
Hardcover $179.99
price for USA in USD
Softcover $179.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Drug-DNA Interaction Protocols
Editors
  • Keith Fox
Series Title
Methods in Molecular Biology
Series Volume
613
Copyright
2010
Publisher
Humana Press
Copyright Holder
Humana Press
Distribution Rights
Distribution rights for India: Mehul Book Sales, Mumbai, India
eBook ISBN
978-1-60327-418-0
DOI
10.1007/978-1-60327-418-0
Hardcover ISBN
978-1-60327-417-3
Softcover ISBN
978-1-61779-674-6
Series ISSN
1064-3745
Edition Number
2
Number of Pages
IX, 311
Number of Illustrations
102 b/w illustrations, 1 illustrations in colour
Additional Information
Originally published as volume 90 in the series: Methods Molecular Biology
Topics