Methods in Molecular Biology

G Protein-Coupled Receptors in Drug Discovery

Editors: Leifert, Wayne R. (Ed.)

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  • Contains several comprehensive reviews of GPCR screening technologies by authoritative leaders
  • Provides an easily accessible reference volume for cell-based GPCR screening written by leading researchers in the field
  • Covers a wide range of assay formats and systems
  • Emphasizes technologies applicable to high throughput screening and research-based, high information content assays
  • Presents a diverse approach to experimental design, covering model biological systems, screening modalities, detection technologies, and approaches to data analysis
  • Comprehensive guide to developing, running, and analyzing cell-based assays in high-throughput screening
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eBook $139.00
price for USA in USD
  • ISBN 978-1-60327-317-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
Hardcover $179.00
price for USA in USD
Softcover $179.00
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About this book

The G protein-coupled receptors (GPCRs), known to be one of the largest superfamilies in the human genome, underpin a multitude of physiological processes and represent a significant target for bioactive and drug discovery programs. In G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, experts in the field provide a range of classic and cutting-edge laboratory protocols developed for GPCR research, as well as several current review articles relevant to the area of high throughput GPCR screening, with discussion on GPCR structure and GPCR signalling. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easy to use, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols serves to aid all those who wish to further the vital research in their GPCR drug discovery programs.

Reviews

From the reviews: “To fully understand the GPCR drug discovery process one should … have wide knowledge of the methods/protocols used in this process. This book serves this exact purpose. … It’s biggest strength is a clear description of every aspect of GPCR drug discovery process, which is easy to understand even for a non-expert in the respective field. … a must-read for everyone involved in GPCR drug discovery and particularly for scientists working in multidisciplinary teams, who need to soundly communicate ideas with experts in other fields.” (Bartosz Trzaskowski, Acta Biochimica Polonica, Vol. 56, December, 2009)

Table of contents (26 chapters)

Table of contents (26 chapters)
  • New Insights into GPCR Function: Implications for HTS

    Pages 1-13

    Eglen, Richard M. (et al.)

  • Screening Technologies for G Protein-Coupled Receptors: From HTS to uHTS

    Pages 15-37

    los Frailes, Maite (et al.)

  • GPCR Signaling: Understanding the Pathway to Successful Drug Discovery

    Pages 39-50

    Williams, Christine (et al.)

  • An Overview on GPCRs and Drug Discovery: Structure-Based Drug Design and Structural Biology on GPCRs

    Pages 51-66

    Lundstrom, Kenneth

  • Understanding the Ligand–Receptor–G Protein Ternary Complex for GPCR Drug Discovery

    Pages 67-77

    Ratnala, Venkata R.P. (et al.)

Buy this book

eBook $139.00
price for USA in USD
  • ISBN 978-1-60327-317-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
Hardcover $179.00
price for USA in USD
Softcover $179.00
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
G Protein-Coupled Receptors in Drug Discovery
Editors
  • Wayne R. Leifert
Series Title
Methods in Molecular Biology
Series Volume
552
Copyright
2009
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-60327-317-6
DOI
10.1007/978-1-60327-317-6
Hardcover ISBN
978-1-60327-316-9
Softcover ISBN
978-1-4939-5706-4
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XI, 376
Topics