Regulatory Networks in Stem Cells

1. Front Matter

   Pages i-xxi

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2. Molecular Regulation in Stem Cells

   1. Front Matter

      Pages 1-1

      PDF

   2. The Molecular Basis of Embryonic Stem Cell Self-Renewal

      • Stephen Dalton

      Pages 3-12

   3. Asymmetric Behavior in Stem Cells

      • Bridget M. Deasy

      Pages 13-26

   4. Determinants of Pluripotency in Mouse and Human Embryonic Stem Cells

      • Leon M. Ptaszek, Chad A. Cowan

      Pages 27-36

   5. Maintenance of Embryonic Stem Cell Pluripotency by Nanog-Mediated Dedifferentiation of Committed Mesoderm Progenitors

      • Atsushi Suzuki, Ángel Raya, Yasuhiko Kawakami, Masanobu Morita, Takaaki Matsui, Kinichi Nakashima et al.

      Pages 37-53

   6. Human Embryonic Stem Cells and Germ Cell Development

      • Nina J. Kossack, Joerg Gromoll, Renee A. Reijo Pera

      Pages 55-66

   7. Genomic Stability in Stem Cells

      • Irene Riz, Robert G. Hawley

      Pages 67-74

   8. Genetic Manipulation of Human Embryonic Stem Cells

      • Dimitris G. Placantonakis, Mark J. Tomishima, Fabien G. Lafaille, Lorenz Studer

      Pages 75-86

   9. Transcriptional Networks Regulating Embryonic Stem Cell Fate Decisions

      • Emily Walker, William L. Stanford

      Pages 87-100

   10. Use of Zebrafish to Dissect Gene Programs Regulating Hematopoietic Stem Cells

       • Colleen E. Albacker, Leonard I. Zon

       Pages 101-110

   11. HOXB4 in Hematopoietic Stem Cell Regulation

       • Mohan C. Vemuri

       Pages 111-122

   12. Telomere and Telomerase for the Regulation of Stem Cells

       • Eiso Hiyama, Keiko Hiyama

       Pages 123-134

   13. The Role of Mitochondria in Stem Cell Biology

       • Claudia Nesti, Livia Pasquali, Michelangelo Mancuso, Gabriele Siciliano

       Pages 137-143

3. Regulation by Stem Cell Niches

   1. Front Matter

      Pages 145-145

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   2. Stem Cells and Stem Cell Niches in Tissue Homeostasis: Lessons from the Expanding Stem Cell Populations of Drosophila

      • Yukiko M. Yamashita

      Pages 147-154

   3. Extrinsic and Intrinsic Control of Germline Stem Cell Regulation in the Drosophila Ovary

      • Nian Zhang, Ting Xie

      Pages 155-164

   4. The Niche Regulation of Hematopoietic Stem Cells

      • Hiroko Iwasaki, Toshio Suda

      Pages 165-173

   5. Environmental Signals Regulating Mesenchymal Progenitor Cell Growth and Differentiation

      • Meirav Pevsner-Fischer, Dov Zipori

      Pages 175-184

   6. Microenvironmental Regulation of Adult Mesenchymal Stem Cells

      • Thomas P. Lozito, Catherine M. Kolf, Rocky S. Tuan

      Pages 185-210

Stem cells appear to be fundamental cellular units associated with the origin of multicellular organisms and have evolved to function in safeguarding the cellular homeostasis in organ t- sues. The characteristics of stem cells that distinguish them from other cells have been the fascinating subjects of stem cell research. The important properties of stem cells, such as ma- tenance of quiescence, self-renewal capacity, and differentiation potential, have propelled this exciting ?eld and presently form a common theme of research in developmental biology and medicine. The derivation of pluripotent embryonic stem cells, the prospective identi?cation of multipotent adult stem cells, and, more recently, the induced pluripotent stem cells (popularly called iPS) are important milestones in the arena of stem cell biology. Complex networks of transcription factors, different signaling molecules, and the interaction of genetic and epi- netic events constantly modulate stem cell behavior to evoke programming and reprogramming processes in normal tissue homeostasis during development. In any given cellular scenario, the regulatory networks can pose considerable complexity and yet exert an orderly control of stem cell differentiation during normal development. An aberration in these ?nely tuned processes during development usually results in a spectrum of diseases such as cancers and neurological disorders. Thisunderscorestheimminentneedforamorecompleteunderstandingofmolecular mechanisms underlying the regulatory circuitries required for stem cell maintenance. Overthepast3–5years,adiversegroupofbenchandphysicianscientistshaveprospectively enhanced our knowledge of stem cell biology. These studies are unveiling many unrecognized or previously unknown fundamentals ofdevelopmental biology.

• DNA
• Expression
• Telomere
• anatomy
• cells
• developmental biology
• endothelium
• gene expression
• genes
• genetics
• miRNAs
• molecular biology
• ontogeny
• surgery
• transcription

From the reviews: “This volume is an initial attempt to decipher the key factors involved in stem cell pluripotency, maintenance, and directed differentiation toward specific cell lineages and stem cell types. The presentation of the contents is such that upper-grade undergraduates, graduate students, postgraduates, and basic research as well as clinical research scientists are provided with accessible information about recent advances in the stem cell field. The volume consists of 43 comprehensively written chapters divided into five parts … .” (Anticancer Research, Vol. 29 (11), November, 2009)

• Memorial Sloan-Kettering Cancer Center, New York, USA

  Vinagolu K. Rajasekhar

• Invitrogen Corporation, Frederick, USA

  Mohan C. Vemuri

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