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Methods in Molecular Biology

Proteases and Cancer

Methods and Protocols

Editors: Antalis, Toni M., Bugge, Thomas H. (Eds.)

  • Presents cutting-edge technologies for the analysis of protease activity, function and substrate detection
  • Contains step-by-step methods and examples
  • Details a wide range of complementary techniques for analysis of specific protease expression, activities, and essential functions
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Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-1-60327-003-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-1-60327-002-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $159.00
price for USA in USD
  • ISBN 978-1-62703-944-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Proteases decisively contribute to cancer development and promotion by regulating the activities of growth factors/cytokines and signaling receptors, as well as the composition of the extracellular matrix, thereby suppressing cell death pathways and activating cell survival pathways. In Proteases and Cancer: Methods and Protocols, expert researchers bring together a wide range of current, complimentary techniques that have been developed for the specific detection and analysis of proteases and their activities in cancer biology. The volume covers vital topics including the application of proteomics technologies for the detection of protease expression in tumors, imaging proteases by activity profiling, proteomics technologies for the identification of biological substrates, detection of cell surface proteolysis, imaging of protease activity, the use of transgenic mice to determine protease function in tumor initiation and progression, and the development of anti-protease therapies for cancer. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easy to use, Proteases and Cancer: Methods and Protocols is an ideal guide for scientists who wish to pursue the study of this important branch of cancer research and the development of unique innovative technologies to aid in that study.

Reviews

From the reviews:

"Proteases and Cancer Methods and Protocols contains chapters written by many of the leading researchers in the field. The book gets off to an excellent start with a very comprehensive and easy to follow review of the role of proteases in cancer. … The quality of the different chapters is generally high … . The book … would be a worthwhile buy for PhD students or postdocs starting out in this field, and institutional libraries." (Erik Sahai, Microbiology Today, November, 2009)


Table of contents (11 chapters)

  • Delineating Protease Functions During 
Cancer Development

    Affara, Nesrine I. (et al.)

    Pages 1-32

  • Proteolytic Systems: Constructing Degradomes

    Ordóñez, Gonzalo R. (et al.)

    Pages 33-47

  • Microarrays for Protease Detection in Tissues and Cells

    Moin, Kamiar (et al.)

    Pages 49-57

  • Positional Scanning Synthetic Combinatorial Libraries for Substrate Profiling

    Schneider, Eric L. (et al.)

    Pages 59-78

  • Mixture-Based Peptide Libraries for Identifying Protease Cleavage Motifs

    Turk, Benjamin E.

    Pages 79-91

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-1-60327-003-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-1-60327-002-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $159.00
price for USA in USD
  • ISBN 978-1-62703-944-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Proteases and Cancer
Book Subtitle
Methods and Protocols
Editors
  • Toni M. Antalis
  • Thomas H. Bugge
Series Title
Methods in Molecular Biology
Series Volume
539
Copyright
2009
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-60327-003-8
DOI
10.1007/978-1-60327-003-8
Hardcover ISBN
978-1-60327-002-1
Softcover ISBN
978-1-62703-944-4
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XII, 221
Topics