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Methods in Molecular Biology

Protocols in Human Molecular Genetics

Authors: Mathew, Christopher G.

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About this book

Extraordinary advances have been made in the field of human molecular genetics during the past five years. The ability to amplify a specific region ofDNA a millionfold in a few hours using the polymerase chain reaction has led to the rapid identification of mutations in human disease and of DNA sequence polymorphisms on every human chro- some. DNA fragments of up to 1 megabase in length can now be resolved by pulsed-field gel electrophoresis to create long-range physical maps of important regions of the genome, and can be cloned in the form of yeast artificial chromosomes. The discovery of highly variable "minisatellite" DNA sequences has led to the development of DNA fingerprinting. The application of these techniques to the study of the human genome has culminated in major advances such as the cloning of the cystic fibrosis gene, the construction of genetic linkage maps of each human chro- some, the mapping of many genes responsible for human inherited d- orders, genetic fingerprinting of forensic specimens, and the detection of mutations involved in the development of human tumors. Although many of the new techniques in molecular genetics can be learned relatively easily, it is often difficult for a researcher to obtain all of the relevant information necessary for getting up a technique and applying it successfully. The information available in the research lite- ture often lacks the depth of description that the new user requires.

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Cover[s] virtually all aspects of modern human molecular genetics....This is an excellent text and should be available to all laboratories using molecular biology as it offers precise instruction for the novice and a wide range of new techniques for the experienced researcher. Its popularity can be gauged by the intense interest shown in the book by both research scientists and students in our laboratory. -SGM Quarterly

Table of contents (33 chapters)

Table of contents (33 chapters)

Buy this book

eBook $89.00
price for USA in USD (gross)
  • ISBN 978-1-59259-496-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
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Bibliographic Information

Bibliographic Information
Book Title
Protocols in Human Molecular Genetics
Authors
Series Title
Methods in Molecular Biology
Series Volume
9
Copyright
1992
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-496-2
DOI
10.1385/0896032051
Series ISSN
1064-3745
Edition Number
1
Number of Pages
472
Topics

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