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Methods in Molecular Medicine

New Antibiotic Targets

Editors: Champney, W. Scott (Ed.)

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  • Features novel drug targets including peptide deformylase, ribosome formation, lipopolysaccharide and fatty acid biosynthesis and signal transduction pathways
  • Includes new methods for the assay of RNA polymerase, peptide bond formation, translational initiation, ribosome biogenesis and membrane permeability, as well as methods for target identification by bacterial genome searches
  • Details the activity of novel inhibitors of DNA polymerase, peptide deformylase, membrane transport, efflux pumps and beta-lactamases
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  • ISBN 978-1-59745-246-5
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Softcover $149.00
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About this book

A crisis is developing in the treatment of infectious diseases, with microorganisms frequently showing resistance to currently prescribed antibiotics. Fewer and fewer antimicrobial agents are now available to treat these infections. In "New Antibiotic Targets," W. Scott Champney examines specific techniques which can be used to explore new drug targets and the effectiveness of new antibiotics. By testing new antimicrobial agents and modified existing drugs, the most vulnerable cell processes, such as cell wall and membrane synthesis, DNA replication, RNA transcription and protein synthesis, can be better exploited. This in-depth volume, however, delves even deeper by identifying additional novel cellular targets for these new therapies.

With detailed methods and protocols for the identification and assay of these targets, "New Antibiotic Targets" provides laboratory investigators with the vital tools they need to test the antimicrobial potential of products and to curb the rise of so many infectious diseases.

Reviews

From the reviews:

"This book describes, in specific detail, a variety of methods used to identify cellular components of bacteria that would be good targets for antibiotics. … Those working in laboratories on discovery of new antibiotics are the intended audience. The book is easy to follow and written in a step-wise fashion. It would be easy for laboratory technicians as well as graduate students to follow. … This is a good methods book that contains the latest information on new techniques." (Rebecca T. Horvat, Doody’s Review Service, May, 2008)

"The contributors to each chapter are good and well known names in their fields, providing good coverage of their subjects. I think this book will find utility in the field of drug discovery and target identification specifically from compound libraries … ." (Paul Hoskisson, Microbiology Today, July, 2008)


Table of contents (20 chapters)

Table of contents (20 chapters)
  • Biocomputational Strategies for Microbial Drug Target Identification

    Pages 1-9

    Sakharkar, Kishore R. (et al.)

  • Methods to Assay Inhibitors of DNA Gyrase and Topoisomerase IV Activities

    Pages 11-23

    Fisher, L. Mark (et al.)

  • A Method to Assay Inhibitors of DNA Polymerase IIIC Activity

    Pages 25-36

    Butler, Michelle M. (et al.)

  • Methods to Identify and Characterize Inhibitors of Bacterial RNA Polymerase

    Pages 37-51

    Lynch, A. Simon (et al.)

  • Methods to Assay Inhibitors of tRNA Synthetase Activity

    Pages 53-61

    Dieter, Beyer (et al.)

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-1-59745-246-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-1-58829-915-4
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $149.00
price for USA in USD
  • ISBN 978-1-61737-843-0
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
New Antibiotic Targets
Editors
  • W. Scott Champney
Series Title
Methods in Molecular Medicine
Series Volume
142
Copyright
2008
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59745-246-5
DOI
10.1007/978-1-59745-246-5
Hardcover ISBN
978-1-58829-915-4
Softcover ISBN
978-1-61737-843-0
Series ISSN
1543-1894
Edition Number
1
Number of Pages
XII, 274
Number of Illustrations
51 b/w illustrations
Topics

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