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  • © 2008

Antiangiogenic Agents in Cancer Therapy

  • Current perspectives on state-of-the-art therapies
  • Contains chapters specific to angiogenesis and antiangiogenic treatment of many malignant diseases

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (31 chapters)

  1. Front Matter

    Pages I-XVIII
  2. Basic Biology of Angiogenesis

    1. Front Matter

      Pages 1-1
    2. The Cycle Between Angiogenesis, Perfusion, and Hypoxia in Tumors

      • Mark W. Dewhirst, Yiting Cao, Gordana Vlahovic
      Pages 27-47
    3. The Role of Integrins in Tumor Angiogenesis

      • Aparna R. Aiyer, Judith A. Varner
      Pages 49-71
    4. Tumor Endothelial Cell Abnormalities

      • Andrew C. Dudley, Michael Klagsbrun
      Pages 73-84
    5. The Extracellular Matrix and VEGF Processing

      • Sunyoung Lee, M. Luisa Iruela-Arispe
      Pages 85-97
    6. Endothelial Precursor Cells

      • Rebecca G. Bagley
      Pages 99-115
    7. Role of Pericytes in Angiogenesis

      • Chunhua Lu, Anil K. Sood
      Pages 117-132
    8. Newer Vascular Targets

      • Beverly A. Teicher
      Pages 133-153
    9. Chemokines in Angiogenesis

      • Michael P. Keane, John A. Belperio, Robert M. Strieter
      Pages 155-170
    10. Angiopoietin/Tie2 Signaling Regulates Tumor Angiogenesis

      • Hanako Kobayashi, Laura M. DeBusk, P. Charles Lin
      Pages 171-187
    11. Imaging Angiogenesis

      • Sanjeeva P. Kalva, Saravanan Namasivayam, Dushyant Vasuedeo Sahani
      Pages 189-203
    12. Tumor Blood Vessels

      • Yineng Fu, Janice A. Nagy, Ann M. Dvorak, Harold F. Dvorak
      Pages 205-224
    13. Lymphatic System in the Pathology of Cancer

      • Bronislaw Pytowski
      Pages 225-241
  3. Translational Research in Tumor Angiogenesis

    1. Front Matter

      Pages 243-243
    2. VEGF in the Adult

      • Arindel S.R. Maharaj, Patricia A. D’Amore
      Pages 245-259
    3. Normalization of Tumor Vasculature and Microenvironment

      • Rakesh K. Jain, Tracy T. Batchelor, Dan G. Duda, Christopher G. Willett
      Pages 261-276
    4. Metronomic Low-Dose Antiangiogenic Chemotherapy in Mice and Man

      • Robert S. Kerbel, U. Emmenegger, S. Man, R. Munoz, C. Folkins, Y. Shaked
      Pages 277-296
    5. Small-Molecule Vascular Disrupting Agents in Cancer Therapy

      • Dietmar W. Siemann, Michael R. Horsman
      Pages 297-310

About this book

Antiangiogenesis remains a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge. Antiangiogenic Agents in Cancer Therapy, Second Edition provides a current, up-dated perspective on the state of the art of angiogenesis and therapy with a compendium of scientific findings and approaches to the study of angiogenesis in cancer.  Leaders in the field present chapters on such topics as the environmental influences and the genetic and physiologic abnormalities that mediate angiogenesis and its role in the progression of malignant disease, working models of tumor angiogenesis, and the role of angiogenesis inhibition in the therapy of malignant disease in humans. 

Comprehensive and cutting-edge, Antiangiogenic Agents in Cancer Therapy, Second Edition is an ideal, valuable guide to the most recent advances in the field, and a collection that will be useful for many years to come.

Reviews

From the reviews of the second edition:

"This is a second edition of a well-accepted text on angiogenesis and antiangiogenic agents, particularly on their use in cancer therapy. In addition to the editors, a large number of outstanding investigators have contributed to this book. … This edition is highly recommended to all of those involved in research or the clinical practice of oncology." (Julian L. Ambrus and Clara M. Ambrus, The Journal of Medicine, March, 2008)

Editors and Affiliations

  • Genzyme Corporation, Framingham

    Beverly A. Teicher

  • M. D. Anderson Cancer Center, The University of Texas, Houston

    Lee M. Ellis

Bibliographic Information

  • Book Title: Antiangiogenic Agents in Cancer Therapy

  • Editors: Beverly A. Teicher, Lee M. Ellis

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59745-184-0

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2008

  • Hardcover ISBN: 978-1-58829-870-6Published: 12 December 2007

  • Softcover ISBN: 978-1-4939-5628-9Published: 23 August 2016

  • eBook ISBN: 978-1-59745-184-0Published: 08 January 2008

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 2

  • Number of Pages: XVIII, 559

  • Topics: Cancer Research, Oncology, Surgical Oncology, Pharmacology/Toxicology

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access