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Methods in Molecular Biology

Patch-Clamp Methods and Protocols

Editors: Molnar, Peter, Hickman, James J. (Eds.)

  • Learn how electrophysiology can be best utilized in drug discovery and development
  • Introduces applications of the dynamic clamp method
  • Includes an extensive theoretical treatise concerning single channel kinetic analysis
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eBook $139.00
price for USA in USD (gross)
  • ISBN 978-1-59745-529-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-1-58829-698-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-1-61737-724-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Patch Clamp Methods and Protocols surveys the typical patch clamp applications and advises scientists on identifying problems and selecting the best technique in each instance. The experiments described require a basic level of electrophysiological training and aid the researcher in pursuing new areas of electrophysiology and using the patch clamp technique effectively. Patch Clamp Methods and Protocols is divided into three sections that cover the major areas of patch clamp application: Pharmacology, Physiology, and Biophysics. The first section provides examples and step by step instructions on how to use whole-cell and single-channel patch clamp methods for testing drugs in industrial settings. The second section provides a wide selection of patch clamp applications in physiological studies. The last part focuses on the biophysical applications of the patch clamp method using single channel recordings or statistical analysis of whole-cell currents in order to obtain parameters that describe ion channel properties or transmitter release. Individual techniques are explored within the area that they are applied most often. Researchers will find Patch Clamp Methods and Protocols to be an invaluable aid in the design and execution of a wide variety of patch clamp experiments, both on their own and in conjunction with other state-of-the-art methodologies.

Reviews

From the reviews:

"This book will be helpful to researchers already working in the field of electrophysiology, but also those coming to this field from pharmacological, physiological, and biophysical areas." - Doody's Book Review Service

"'Patch-clamp: Methods and Protocols’ introduces some common patch-clamp applications. It is intended to assist scientists in identifying problems, which could be best addressed by this technique. The book provides the step-by-step procedures to perform the experiments that answer those questions. … It will be a useful companion for moderately advanced users wishing to extend their skills." (Maria Drigelova, General Physiology and Biophysics, Vol. 27, April, 2008)


Table of contents (19 chapters)

  • Pharmacological Analysis of Recombinant NR1a/2A and NR1a/2B NMDA Receptors Using the Whole-Cell Patch-Clamp Method

    Fodor, László (et al.)

    Pages 3-13

  • Memantine as an Example of a Fast, Voltage-Dependent, Open Channel N-Methyl-d-Aspartate Receptor Blocker

    Parsons, Chris G. (et al.)

    Pages 15-36

  • Methods for Evaluation of Positive Allosteric Modulators of Glutamate AMPA Receptors

    Siuda, Edward R. (et al.)

    Pages 37-57

  • Automated Voltage-Clamp Technique

    Ghetti, Andrea (et al.)

    Pages 59-69

  • Flip-the-Tip

    Fejtl, Michael (et al.)

    Pages 71-85

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-1-59745-529-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-1-58829-698-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-1-61737-724-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Patch-Clamp Methods and Protocols
Editors
  • Peter Molnar
  • James J. Hickman
Series Title
Methods in Molecular Biology
Series Volume
403
Copyright
2007
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59745-529-9
DOI
10.1007/978-1-59745-529-9
Hardcover ISBN
978-1-58829-698-6
Softcover ISBN
978-1-61737-724-2
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XI, 321
Number of Illustrations and Tables
71 b/w illustrations
Topics