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Methods in Molecular Biology

Target Discovery and Validation Reviews and Protocols

Emerging Strategies for Targets and Biomarker Discovery, Volume 1

Editors: Sioud, Mouldy (Ed.)

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  • ISBN 978-1-59745-165-9
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Hardcover $199.99
price for USA in USD
  • ISBN 978-1-58829-656-6
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Softcover $199.99
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  • ISBN 978-1-61737-699-3
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About this book

Target discovery is a field that has existed for several years but is so vibrant today because of the recent progress in our understanding of the molecular mechanisms of many human diseases and the technical advances in target identification and validation. More sophisticated gene profiling technologies, such as DNA microarrays and serial analysis of gene expression, permit rapid identification of lead targets. Moreover, analysis of gene networks in living organisms allows the identification of target genes that operate in defined physiological pathways. With the sequencing of several genomes completed and the rapidly growing gene expression databases, there is now greater impetus than ever before for in silico discovery of therapeutic targets. Also, recent advances in genetic technologies have increased our ability to generate mouse models for human diseases. The implications of these genetically modified animals in drug development are several, including identification of new drug targets, predicting efficacy, and uncovering possible side effects. Together, these recent technical advances should allow researchers to make the most informed choice early and advance the chosen targets toward clinical studies. Regarding cancers, any difference between a cancer and a normal cell could potentially be exploited as a therapeutic target. The hope is that drugs targeting specific constituents or pathways in cancer cells will provide more effective therapy, either alone or in combination with other currently used anticancer drugs. In addition to drug targets, identifying new target antigens remains as much of a challenge as improving tumor vaccines already in the clinic.

Reviews

From the reviews:

"Volume 1 focuses on novel and innovative techniques, and presents the most up-to-date protocols available for maximizing the likelihood of achieving target-selective inhibition in vivo while minimizing side effects. … Cancer researchers will find tremendous value in the molecular classification of breast cancers and the review of protocols for tumor antigens and cancer vaccines. … provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application." (Anticancer Research, Vol. 27, May, 2007)

"Review current methods for drug target discovery and validation. … Volume 1 is focused on drug target and biomarker discovery. … the chapters are generally well written and clear, and provide extensive references to the current literature. … Overall … provide useful overviews that would provide entry into this field. Novice and more experienced researchers … would find useful information … ." (Jonathan B. Chaires, ChemMedChem, Issue 3, 2008)


Table of contents (17 chapters)

Table of contents (17 chapters)

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-1-59745-165-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-1-58829-656-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $199.99
price for USA in USD
  • ISBN 978-1-61737-699-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Target Discovery and Validation Reviews and Protocols
Book Subtitle
Emerging Strategies for Targets and Biomarker Discovery, Volume 1
Editors
  • Mouldy Sioud
Series Title
Methods in Molecular Biology
Series Volume
360
Copyright
2007
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59745-165-9
DOI
10.1385/1597451657
Hardcover ISBN
978-1-58829-656-6
Softcover ISBN
978-1-61737-699-3
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XII, 354
Number of Illustrations
86 b/w illustrations, 3 illustrations in colour
Topics