Infectious Disease

Reverse Transcriptase Inhibitors in HIV/AIDS Therapy

Editors: Skowron, Gail, Ogden, Richard (Eds.)

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eBook $219.00
price for USA in USD (gross)
  • ISBN 978-1-59745-085-0
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Hardcover $279.99
price for USA in USD
  • ISBN 978-1-58829-649-8
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Softcover $279.99
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  • ISBN 978-1-61737-695-5
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About this book

Despite significant pharmacological advances, the backbone of the most highly active antiretroviral therapy regimens for controlling HIV/AIDS is still a combination of reverse transcriptase inhibitors (RTIs) first discovered in the late 1980s. In Reverse Transcriptase Inhibitors in HIV/AIDS Therapy, leading experts in AIDS/HIV drug discovery and development review all aspects of RTIs (nucleosides, nucleotides, and non-nucleosides), including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment in general, and on vertical transmission in the developing world. Highlights include a thorough discussion of side effects, resistance, and treatment in the third world.
Comprehensive and up-to-date, Reverse Transcriptase Inhibitors in HIIV/AIDS Therapy offers a magisterial survey of the discovery, clinical development, current use, and future possibilities of all drugs that treat HIV/AIDS by inhibiting the viral reverse transcriptase.

Reviews

From the reviews:

"This book will appeal to medical students needing a detailed review of area … . It is most suitable for libraries … . The individual chapters are authoritative and comprehensive … . a source for in-depth and specific information." (Mark Harris, Microbiology Today, November, 2006)


Table of contents (17 chapters)

Table of contents (17 chapters)

Buy this book

eBook $219.00
price for USA in USD (gross)
  • ISBN 978-1-59745-085-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-1-58829-649-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.99
price for USA in USD
  • ISBN 978-1-61737-695-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Reverse Transcriptase Inhibitors in HIV/AIDS Therapy
Editors
  • Gail Skowron
  • Richard Ogden
Series Title
Infectious Disease
Copyright
2006
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59745-085-0
DOI
10.1007/978-1-59745-085-0
Hardcover ISBN
978-1-58829-649-8
Softcover ISBN
978-1-61737-695-5
Edition Number
1
Number of Pages
XIV, 528
Number of Illustrations
59 b/w illustrations
Topics