Methods in Molecular Biology

Essential Concepts in Toxicogenomics

Editors: Mendrick, Donna L., Mattes, William B. (Eds.)

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  • Includes contributions from experts in fields as diverse as the pharmaceutical industry, biotechnology companies, regulatory agencies, non-profit organizations and academia
  • Covers the many uses of toxicogenomics spanning its predictive application, use in mechanistic analysis, and consideration for risk assessment
  • Discusses the issues that currently limit its universal acceptance including cross species correlations, regulatory uncertainty and biomarker validation
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About this book

The field of toxicogenomics has been growing quickly, yet with rapid growth comes the need to periodically reflect on the nature of the field.  Essential Concepts in Toxicogenomics collects reviews, opinion pieces and case studies from the leading experts in this dynamic field with a focus on its application to pharmaceuticals.  Topics covered include issues that affect the quality of toxicogenomics experiments, statistical approaches to their data analysis, the use of such data to build toxicogenomic models, and the utilization of genomics to identify biomarkers within the preclinical and clinical arenas. Although not in the standard Methods in Molecular Biology™ series format, this volume retains the practicality and usefulness of the highly successful series.

 

Informative and cutting-edge, Essential Concepts in Toxicogenomics is an ideal resource for pharmaceutical companies, chemical manufacturers, toxicologists, and all who must keep up-to-date on progress in this vital and important field.

Reviews

From the reviews:

"‘Essential Concepts in Toxicogenomics’ is a collections of reviews, opinion pieces and case studies written by experts in the field. … gives good coverage of whole field of toxicogenomics. … If you want to get up to steam with this area then … it is certainly worth reading this book." (James Sidaway, BTS Newsletter, Winter, 2008)


Table of contents (12 chapters)

Table of contents (12 chapters)
  • Toxicogenomics and Classic Toxicology: How to Improve Prediction and Mechanistic Understanding of Human Toxicity

    Pages 1-22

    Mendrick, Donna L.

  • Use of Traditional End Points and Gene Dysregulation to Understand Mechanisms of Toxicity: Toxicogenomics in Mechanistic Toxicology

    Pages 23-44

    Buck, Wayne R. (et al.)

  • Quality Control of Microarray Assays for Toxicogenomic and In Vitro Diagnostic Applications

    Pages 45-68

    Thompson, Karol L. (et al.)

  • Role of Statistics in Toxicogenomics

    Pages 69-87

    Elashoff, Michael

  • Predictive Toxicogenomics in Preclinical Discovery

    Pages 89-112

    Barros, Scott A. (et al.)

Buy this book

eBook $119.00
price for USA in USD
  • ISBN 978-1-60327-048-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts from 10 eBooks
Hardcover $159.99
price for USA in USD
Softcover $159.00
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Essential Concepts in Toxicogenomics
Editors
  • Donna L. Mendrick
  • William B. Mattes
Series Title
Methods in Molecular Biology
Series Volume
460
Copyright
2008
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-60327-048-9
DOI
10.1007/978-1-60327-048-9
Hardcover ISBN
978-1-58829-638-2
Softcover ISBN
978-1-61737-688-7
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XI, 277
Topics