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Methods in Molecular Biology

Checkpoint Controls and Cancer

Volume 2: Activation and Regulation Protocols

Editors: Schönthal, Axel H. (Ed.)

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About this book

Intracellular checkpoint controls constitute a network of signal transduction pathways that protect cells from external stresses and internal errors by means of cell cycle arrest, DNA repair, or apoptosis. Failure of this machinery can lead to embryonic death, genetic diseases, and cancer. In Checkpoint Controls and Cancer, Volume 2: Activation and Regulation Protocols, Axel H. Schönthal, PhD, marshals a prestigious panel of researchers working at the cutting edges of their fields to present readily reproducible experimental protocols for the study of the molecular components of checkpoint controls and their regulation. Described in step-by-step detail, these powerful techniques offer such novel approaches as the use of genome databases and siRNA to analyze how cells of the human body can escape proper surveillance to grow into a tumor. Additional experimental methods are provided for the manipulation of checkpoint pathways and the analysis of the resulting consequences for the cellular phenotype. The earlier first volume, Reviews and Model Systems, comprehensively describes the complexities of checkpoint controls and the model systems available to study them.
Comprehensive and up-to-date, the two volumes of Checkpoint Controls and Cancer offer novice and experienced researchers alike not only entré into the complexities of this vast field, but also to the full panoply of productive tools needed to deepen understanding of the systems, as well as to develop new and more effective therapies.

Table of contents (24 chapters)

Table of contents (24 chapters)
  • Analysis of RB Action in DNA Damage Checkpoint Response

    Pages 3-16

    Mayhew, Christopher N. (et al.)

  • Interaction Between the Retinoblastoma Protein and Protein Phosphatase 1 During the Cell Cycle

    Pages 17-32

    Berndt, Norbert (et al.)

  • Generation of p53 Target Database Via Integration of Microarray and Global p53 DNA-Binding Site Analysis

    Pages 33-54

    Liu, Suxing (et al.)

  • Functional Analysis of CDK Inhibitor p21WAF1

    Pages 55-71

    Fotedar, Rati (et al.)

  • Analysis of p21CDKN1A Recruitment to DNA Excision Repair Foci in the UV-Induced DNA Damage Response

    Pages 73-89

    Stivala, Lucia A. (et al.)

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-1-59259-811-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.00
price for USA in USD
  • ISBN 978-1-58829-500-2
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $179.00
price for USA in USD
  • ISBN 978-1-61737-603-0
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Checkpoint Controls and Cancer
Book Subtitle
Volume 2: Activation and Regulation Protocols
Editors
  • Axel H. Schönthal
Series Title
Methods in Molecular Biology
Series Volume
281
Copyright
2004
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-811-3
DOI
10.1385/1592598110
Hardcover ISBN
978-1-58829-500-2
Softcover ISBN
978-1-61737-603-0
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XVIII, 358
Topics

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