40% off Popular Science books & eBooks—Save on general interest titles now!

Cancer Drug Discovery and Development

The Oncogenomics Handbook

Editors: LaRochelle, William J., Shimkets, Richard A. (Eds.)

Free Preview

Buy this book

eBook $299.00
price for USA in USD
  • ISBN 978-1-59259-893-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $379.99
price for USA in USD
  • ISBN 978-1-58829-425-8
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
About this book

Bioinformatic integration of the findings from recent genomic and proteomic research has made possible the development of highly selective therapeutics that can target specific cellular pathways controlling cell proliferation, differentiation, metastasis, evasion of immune surveillance, angiogenesis, and apoptosis. In The Oncogenomics Handbook, a panel of internationally recognized researchers and clinicians provides an integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following that path, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including rituximab, Herceptin®, Avastin™, ABGX-EGF, Velcade®, Iressa®, and Zevalin® are addressed. Additional chapters review clinical diagnostics, bioanalytics, and biomarkers and their importance to therapeutic outcome; detail antiangiogenic, supportive, immunomodulatory, and tumor-targeted approaches to cancer therapy; and provide a systems biology-bioinformatics overview of strategies and initiatives for the postgenomic era. Highlights include cancer genomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.
Authoritative and state-of-the-art, The Oncogenomics Handbook offers cancer researchers and drug developers a comprehensive update on the contribution of the genomic revolution to cancer drug discovery and development.

Reviews

"...an excellent resource to anyone interested in the field of cancer or cancer research. Its comprehensive overview of different perspectives in oncologic genomics will certainly be beneficial to a wide range of professionals in their ultimate endeavors towards further development of advanced cancer therapies." - Doody's Health Sciences and Book Review Journal

"...provides an integrated overview of cancer drug discovery and development...." - BioTech International

Table of contents (44 chapters)

Table of contents (44 chapters)
  • Genomic Resources for Cancer Biologists

    Pages 3-17

    Ling, Xuefeng Bruce, PhD (et al.)

  • Cancer Drug Target Identification by SAGE, LongSAGE, and Digital Karyotyping

    Pages 19-30

    Hermeking, Heiko, PhD

  • Identification of Novel Cancer Target Antigens Utilizing EST and Genome Sequence Databases

    Pages 31-42

    Bera, Tapan K., PhD (et al.)

  • Tree-Based Cancer Classification and Diagnosis Using Gene Expression Data

    Pages 43-51

    Zhang, Heping, PhD

  • From FISH to Proteomics

    Pages 53-67

    Subramanian, Balanehru, PhD (et al.)

Buy this book

eBook $299.00
price for USA in USD
  • ISBN 978-1-59259-893-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $379.99
price for USA in USD
  • ISBN 978-1-58829-425-8
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
The Oncogenomics Handbook
Editors
  • William J. LaRochelle
  • Richard A. Shimkets
Series Title
Cancer Drug Discovery and Development
Copyright
2005
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-893-9
DOI
10.1385/1592598935
Hardcover ISBN
978-1-58829-425-8
Series ISSN
2196-9906
Edition Number
1
Number of Pages
XVII, 750
Topics