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Methods in Molecular Biology

Protein'Ligand Interactions

Methods and Applications

Editors: Nienhaus, G. Ulrich (Ed.)

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About this book

Molecular recognition and binding of ligands (atoms, ions, and molecules) by proteins with high sensitivity and selectivity is of central importance to essentially all biomolecular processes and of key importance for the basic and applied sciences. In Protein-Ligand Interactions: Methods and Applications, leading experts with hands-on experience describe in detail a broad selection of established and emerging techniques for studying the interaction between proteins and ligands, including bulk biochemical techniques, structure analysis, spectroscopy, single-molecule studies, and theoretical/computational tools. Among the highlights are surface plasmon resonance (SPR) and reflectometric biosensor approaches, high-throughput screening with confocal optics microscopy, single molecule fluorescence and fluorescence correlation spectroscopy (FCS), atomic force microscopy (AFM), crystallography of reaction intermediates, and time-resolved X-ray crystallography. The protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and highly practical, Protein-Ligand Interactions: Methods and Applications offers novice and expert researchers alike a broad selection of powerful and widely applicable techniques that can be used to efficiently and successfully solve the task of characterizing protein-ligand interactions.

Table of contents (24 chapters)

  • Isothermal Titration Calorimetry

    Lewis, Edwin A. (et al.)

    Pages 1-15

  • Direct Optical Detection of Protein-Ligand Interactions

    Gesellchen, Frank (et al.)

    Pages 17-45

  • Label-Free Detection of Protein-Ligand Interactions by the Quartz Crystal Microbalance

    Janshoff, Andreas (et al.)

    Pages 47-63

  • Measurement of Solvent Accessibility at Protein-Protein Interfaces

    Mandell, Jeffrey G. (et al.)

    Pages 65-79

  • Hydrophobic Interaction Chromatography

    Jennissen, Herbert P.

    Pages 81-99

Buy this book

eBook $199.00
price for USA in USD (gross)
  • ISBN 978-1-59259-912-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA in USD
  • ISBN 978-1-58829-372-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA in USD
  • ISBN 978-1-61737-525-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Protein'Ligand Interactions
Book Subtitle
Methods and Applications
Editors
  • G. Ulrich Nienhaus
Series Title
Methods in Molecular Biology
Series Volume
305
Copyright
2005
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-912-7
DOI
10.1385/1592599125
Hardcover ISBN
978-1-58829-372-5
Softcover ISBN
978-1-61737-525-5
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XI, 568
Topics