Arthritis Research

Arthritis Research: Methods and Protocols is a compendium of data pertinent to the methods and protocols that have contributed to recent advances in molecular medicine in general, but to the molecular basis of rheumatic disease in particular. These volumes details novel technologies, some of which are still evolving and whose impacts are yet to be determined. Leaders in the field contribute to cover such exciting and cutting edge topics as imaging and immunohistochemistry, analysis of cartilage and bone catabolism, immunobiology, and cell trafficking.

In Volume 1, authors discuss synovial joint morphology, histopathology, and immunohistochemistry, cartilage matrix and bone biology, and cell trafficking, migration and invasion. Volume 2 is broken up into sections that cover immunobiology and T cells, animal models of arthritis, and applications of new technologies, such as Differential Display Reverse Transcription-Polymerase Chain Reaction (DDRT-PCR), to define novel therapeutic targets. Both volumes combine to produce a concise set of protocols condensing decades of experience and expertise.

Arthritis Research: Methods and Protocols will be a valuable tool for basic research investigators, clinician scientists, pathologists, immunologists, and biochemists looking to stay current in their fields.

• Arthritis
• PCR
• gene expression
• gene transfer
• genes
• hybridization
• microscopy
• transcription

From the reviews:

"...offers a comprehensive reference for the analysis of tissues relevant to arthritis research in brief chapters that emphasize how various analyses are performed.  What separates this series from other references in this area is its ability to be brief but thorough in the discussion of technically challenging methods." -Doody's Book Review, Weighted Numerical Score:95 - 4 Stars

"This multiauthored … compendium of arthritis research methods and protocols provides pertinent practical information for the bench researcher as well as for the interested clinician. … It is a worthwhile reference to have in the research laboratory … . I enthusiastically recommend … and believe this publication would have broad appeal to the rheumatologic community and to those in related specialties. … I congratulate the authors on developing an excellent compendium of arthritis research … ." (Robert J. Quinet, JAMA, April, 2008)

"Arthritis Research: Methods and Protocols forms part of a book series on Methods in Molecular Medicine by Humana Press. … Overall the books are extremely useful as both a practical guide and a reference text and are easy to understand. We would recommend the books to anyone with an interest in rheumatology research – basic scientists, clinicians and students … ." (Leonie Taams and Hayley Evans, Immunology News, August, 2008)

• The Kennedy Institute of Rheumatology, Imperial College London, London, UK

  Andrew P. Cope

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