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Cancer Drug Discovery and Development

Deoxynucleoside Analogs in Cancer Therapy

Editors: Peters, Godefridus J (Ed.)

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  • ISBN 978-1-59745-148-2
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Hardcover $279.99
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Softcover $279.99
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  • ISBN 978-1-61737-497-5
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About this book

Emerging as an important new volume in the renowned Cancer Drug Discovery and Development™ series, Deoxynucleoside Analogs in Cancer Therapy expertly summarizes the current status of development and application of deoxynucleoside analogs. Authoritative up-to-date reviews are presented by scientists well known in their specific areas and all contributions include valuable sound advice on structure and topics.
Organized into several sections, the first part covers general aspects of drug uptake and metabolism and explains how novel technology has enabled a rapid expansion of this field. The second part is concerned with a number of specific drugs including cytarabine, gemcitabine, troxacitabine, clofarabine and Ara-G. The final section covers pharmacokinetics, prodrugs, and specific applications such as radiosensitization, gene therapy, and the use of deoxynucleoside analogs as tracers.
Throughout Deoxynucleoside Analogs in Cancer Therapy, the focus is on novel aspects of deoxynucleoside analogs in the clinical context, as well as on unexpected targets of these compounds, such as their specific activity against cell cycle-dependent kinases or oncogenes. The wealth of information presented here can be used to design rational combinations aimed at inhibiting various cellular signaling pathways, or combining inhibition of various targets. Deoxynucleoside Analogs in Cancer Therapy has been designed specifically to facilitate such an interaction between various fields.

Reviews

"...a top-notch overview of the current knowledge in the area of deoxynucleoside analog development and application in the treatment of cancer."  -Weighted Numerical Score: 92 - 4 Stars!-Doody's Health Science Book Review Journal

 

"...an excellent book that is suitable for researchers or clinicians with an interest in deoxynucleoside analgos and/or cancer chemotherapy."  -Weighted Numerical Score: 92 - 4 Stars!-Doody's Health Science Book Review Journal


Table of contents (17 chapters)

Table of contents (17 chapters)
  • Nucleoside Transport Into Cells

    Pastor-Anglada, Marçal, MSc, PhD (et al.)

    Pages 1-28

  • The Role of Deoxycytidine Kinase in DNA Synthesis and Nucleoside Analog Activation

    Staub, Maria, MD, PhD, ScD (et al.)

    Pages 29-52

  • Deoxynucleoside Kinases and Their Potential Role in Deoxynucleoside Cytotoxicity

    Munch-Petersen, Birgitte, DSc (et al.)

    Pages 53-79

  • Nucleotidases and Nucleoside Analog Cytotoxicity

    Hunsucker, Sally Anne, PhD (et al.)

    Pages 81-108

  • Pumping Out Drugs

    Borst, Piet, MD, PhD (et al.)

    Pages 109-117

Buy this book

eBook $219.00
price for USA in USD (gross)
  • ISBN 978-1-59745-148-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-1-58829-327-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.99
price for USA in USD
  • ISBN 978-1-61737-497-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Deoxynucleoside Analogs in Cancer Therapy
Editors
  • Godefridus J Peters
Series Title
Cancer Drug Discovery and Development
Copyright
2006
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59745-148-2
DOI
10.1007/978-1-59745-148-2
Hardcover ISBN
978-1-58829-327-5
Softcover ISBN
978-1-61737-497-5
Series ISSN
2196-9906
Edition Number
1
Number of Pages
XIV, 476
Topics