Cancer Drug Discovery and Development

The Role of Microtubules in Cell Biology, Neurobiology, and Oncology

Editors: Fojo, Antonio Tito (Ed.)

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  • Collects the most current microtubule research available
  • Investigates the potential of microtubules in cancer therapy
  • Written by leading anti-cancer researchers
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Hardcover $349.99
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Softcover $279.99
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About this book

The family of proteins called the tubulin and the microtubules they form when they aggregate are extremely important in the cell and, as we are increasingly learning, important in diseases that afflict so many. This field of investigation is a testament to how important both basic and clinical sciences are in understanding disease mechanisms and making inroads into therapies. Microtubule Targets in Cancer Therapy presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available. Among the topics examined in this volume are compounds that interact with tubulin, mechanisms and regulation by microtubule-associated proteins and drugs, MAPs, the tubulin superfamily its isotopes, peptides and depsipeptides, and neurodegenerative diseases.

Without the basic scientific knowledge that has been accumulated – to which the contributors of this work have contributed greatly – we would not be in the position we find ourselves as we increasingly understand disease and advancing therapies. Microtubule Targets in Cancer Therapy contributes to this new knowledge, and the text will be an invaluable resource for cancer researchers, oncologists, pharmacologists, and medical chemists.

Reviews

From the reviews:

"This book is appropriate for laboratories with an interest in the biology of microtubules … . Each chapter is nicely illustrated, well referenced, and offers a timely evaluation of what is known about tubulin and microtubules, including how they are targeted therapeutically. … The color insert and the accompanying CD-ROM with all color figures are helpful. This is an excellent all-around reference appropriate for researchers or clinicians interested in the basic science of tubulins, microtubules, related diseases, and targeted therapy."(John D. Robertson, Doody’s Review Service, January, 2009)

“This book offers a wide and detailed discussion of drugs and methods for studying tubulins and microtubules … . The book is easy-reading and well organized by … well-detailed and itemized methodology of study, a helpful conclusion including tips for future interested investigators, and a long list of references serving a specific source of search. … Chapters added in the end of the book … very nicely wrap up the book for those interested in these areas and hopefully intending to acquire acknowledgement about it.” (Fábio Luís Forti, Brazilian Journal of Pharmaceutical Sciences, Vol. 47 (2), Summer, 2011)


Table of contents (21 chapters)

Table of contents (21 chapters)
  • An Overview of Compounds That Interact with Tubulin and Their Effects on Microtubule Assembly

    Pages 1-19

    Hamel, Ernest, MD

  • Molecular Mechanisms of Microtubule Acting Cancer Drugs

    Pages 21-46

    Correia, John J., PhD (et al.)

  • Microtubule Dynamics

    Pages 47-81

    Jordan, Mary Ann, PhD (et al.)

  • Microtubule-Associated Proteins and Microtubule-Interacting Proteins

    Pages 83-104

    Kavallaris, Maria, PhD (et al.)

  • The Post-Translational Modifications of Tubulin

    Pages 105-121

    Ludueña, Richard F., PhD (et al.)

Buy this book

eBook $219.00
price for USA in USD
  • ISBN 978-1-59745-336-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $349.99
price for USA in USD
  • ISBN 978-1-58829-294-0
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $279.99
price for USA in USD
  • ISBN 978-1-62703-861-4
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
The Role of Microtubules in Cell Biology, Neurobiology, and Oncology
Editors
  • Antonio Tito Fojo
Series Title
Cancer Drug Discovery and Development
Copyright
2008
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59745-336-3
DOI
10.1007/978-1-59745-336-3
Hardcover ISBN
978-1-58829-294-0
Softcover ISBN
978-1-62703-861-4
Series ISSN
2196-9906
Edition Number
1
Number of Pages
XVII, 587
Topics