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Biomarkers in Breast Cancer

  • Book
  • © 2006

Overview

Editors:
  1. Giampietro Gasparini

    1. Division of Medical Oncology, “San Filippo Neri” Hospital, Rome, Italy

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  2. Daniel F. Hayes

    1. Breast Oncology Program, University of Michigan Comprehensive Cancer Center, Ann Arbor

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xi
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  2. General Topics

    1. Front Matter

      Pages 1-1
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    2. Guidelines for the Design of Clinical Studies for the Development and Validation of Therapeutically Relevant Biomarkers and Biomarker-Based Classification Systems

      • Richard M. Simon
      Pages 3-15

    3. Analytical Aspects of Biomarker Immunoassays in Cancer Research

      • Fred C. G. J. Sweep, Chris M. G. Thomas, Manfred Schmitt
      Pages 17-30

    4. Tissue Microarrays

      • Chungyeul Kim, Soonmyung Paik
      Pages 31-44

  3. Assays for Gene Expression and Post-Translational Protein Abnormalities

    1. Front Matter

      Pages 45-45
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    2. Gene Expression Profiling with DNA Microarrays

      • Michele De Bortoli, Nicoletta Biglia
      Pages 47-61

  4. Assays for DNA Abnormalities

    1. Front Matter

      Pages 63-63
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    2. Assays for Gene Amplification

      • Chungyeul Kim, Yongkuk Song, Soonmyung Paik
      Pages 65-77

  5. Tissue Predictive Biomakers

    1. Front Matter

      Pages 79-79
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    2. Cell Kinetics

      • Maria Grazia Daidone, Rosella Silvestrini, Dino Amadori
      Pages 81-109

    3. Urokinase-Type Plasminogen Activator and PAI-1

      • Michael J. Duffy
      Pages 111-128

    4. Predictive Value of c--erb-B2 for Endocrine Therapy and Chemotherapy in Breast Cancer

      • Vered Stearns
      Pages 129-157

    5. erb-B2 as a Therapeutic Target

      • Robert Mass
      Pages 159-175

    6. The Epidermal Growth Factor Receptor Pathway as a Selective Molecular-Targeted Treatment in Human Breast Cancer

      • Fortunato Ciardiello, Teresa Troiani, Giampaolo Tortora
      Pages 177-191

    7. p53 as a Prognostic and Predictive Indicator

      • Daniela Kandioler, Raimund Jakesz
      Pages 193-209

  6. Predictive Biomarkers in Body Fluids

    1. Front Matter

      Pages 211-211
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    2. Occult Metastatic Cells in Breast Cancer Patients

      • Stephan Braun, Julia Seeber, Christian Marth
      Pages 213-233

    3. Circulating HER2/neu

      • Allan Lipton, Laurence Demers, Kim Leitzel, Suhail M. Ali, Rainer Neumann, Christopher P. Price et al.
      Pages 235-265

    4. Circulating Vascular Endothelial Growth Factor

      • Roberta Sarmiento, Roberta Franceschini, Sabrina Meo, Massimo Gion, Raffele Longo, Giampietro Gasparini
      Pages 267-292
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Keywords

About this book

Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.

Editors and Affiliations

  • Division of Medical Oncology, “San Filippo Neri” Hospital, Rome, Italy

    Giampietro Gasparini

  • Breast Oncology Program, University of Michigan Comprehensive Cancer Center, Ann Arbor

    Daniel F. Hayes

Bibliographic Information

  • Book Title: Biomarkers in Breast Cancer

  • Editors: Giampietro Gasparini, Daniel F. Hayes

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1385/159259915X

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Humana Press 2006

  • Hardcover ISBN: 978-1-58829-227-8Published: 01 October 2005

  • Softcover ISBN: 978-1-61737-436-4Published: 01 December 2010

  • eBook ISBN: 978-1-59259-915-8Published: 17 January 2008

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XII, 342

  • Number of Illustrations: 22 b/w illustrations

  • Topics: Cancer Research

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