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Cancer Drug Discovery and Development

Biomarkers in Breast Cancer

Editors: Gasparini, Giampietro, Hayes, Daniel F. (Eds.)

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eBook $219.00
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  • ISBN 978-1-59259-915-8
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Hardcover $279.99
price for USA in USD
  • ISBN 978-1-58829-227-8
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Softcover $279.99
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  • ISBN 978-1-61737-436-4
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About this book

It is now well recognized that individualized cancer treatment planning, based on tumor characteristics specific to an individual's cancer, makes it easier to select those most likely to benefit from toxic cancer therapies and to avoid treating those least likely to benefit. In Biomarkers in Breast Cancer: Molecular Diagnostics for Predicting and Monitoring Therapeutic Effect, expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers, as well as examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines to the validation of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.
Authoritative and cutting-edge, Biomarkers in Breast Cancer: Molecular Diagnostics for Predicting and Monitoring Therapeutic Effect offers laboratory investigators developing new tumor markers, clinical investigators testing them, and clinicians using them an up-to-date understanding of both the prognostic/predictive indicators and the novel molecular-targeted therapies suitable for individualizing breast cancer therapy.

Table of contents (16 chapters)

Table of contents (16 chapters)
  • Guidelines for the Design of Clinical Studies for the Development and Validation of Therapeutically Relevant Biomarkers and Biomarker-Based Classification Systems

    Pages 3-15

    Simon, Richard M., DSc

  • Analytical Aspects of Biomarker Immunoassays in Cancer Research

    Pages 17-30

    Sweep, Fred C. G. J., PhD (et al.)

  • Tissue Microarrays

    Pages 31-44

    Kim, Chungyeul, MD (et al.)

  • Gene Expression Profiling with DNA Microarrays

    Pages 47-61

    Bortoli, Michele, PHD (et al.)

  • Assays for Gene Amplification

    Pages 65-77

    Kim, Chungyeul, MD (et al.)

Buy this book

eBook $219.00
price for USA in USD (gross)
  • ISBN 978-1-59259-915-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-1-58829-227-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.99
price for USA in USD
  • ISBN 978-1-61737-436-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Biomarkers in Breast Cancer
Editors
  • Giampietro Gasparini
  • Daniel F. Hayes
Series Title
Cancer Drug Discovery and Development
Copyright
2006
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-915-8
DOI
10.1385/159259915X
Hardcover ISBN
978-1-58829-227-8
Softcover ISBN
978-1-61737-436-4
Series ISSN
2196-9906
Edition Number
1
Number of Pages
XII, 342
Number of Illustrations
22 b/w illustrations
Topics