Handbook of Cancer Vaccines

1. Front Matter

   Pages i-xvii

   PDF

2. Basic Science of Tumor Antigens and Immune Activation

   1. Front Matter

      Pages 1-1

      PDF

   2. Biology of the Cancer Vaccine Immune Response

      • Michael A. Morse, Timothy M. Clay, H. Kim Lyerly

      Pages 3-10

   3. The Rational Design of T-Cell Epitopes With Enhanced Immunogenicity

      • John Fikes

      Pages 11-17

   4. Identification of Tumor Antigens Using Subtraction and Microarrays

      • Jiangchun Xu

      Pages 19-29

   5. Tumor Antigen Discovery With T Cells

      • Paul F. Robbins

      Pages 31-47

   6. Targeting Viral Antigens for the Treatment of Malignancies

      • Gretchen L. Eiben, Diane M. Da Silva, Steven C. Fausch, Amanda M. Krier, I. Caroline Le Poole, Megan E. Papineau et al.

      Pages 49-64

   7. Immune Defects in Cancer

      • Dmitry Gabrilovich, Vladimir Pisarev

      Pages 65-84

   8. Escape of Tumors From the Immune System

      • Gerard C. Blobe

      Pages 85-95

3. General Vaccine and Immunotherapy Strategies

   1. Front Matter

      Pages 97-97

      PDF

   2. Immune Adjuvants

      • Jory R. Baldridge, Susan Hand Zimmermann, Sally P. Mossman

      Pages 99-114

   3. Heterologous Prime-Boost Vaccination in Tumor Immunotherapy

      • Michael J. Palmowski, Caroline Smith

      Pages 115-120

   4. Peptide-Based Vaccines

      • Carmen M. Berger, Keith L. Knutson, Lupe G. Salazar, PA-C Kathy Schiffman, Mary L. Disis

      Pages 121-135

   5. Antibody-Inducing Cancer Vaccines Against Cell-Surface Carbohydrate Antigens

      • Govind Ragupathi, John Gathuru, Philip O. Livingston

      Pages 137-155

   6. Anti-Idiotype Vaccines

      • Sunil K. Chatterjee, Malaya Bhattacharya-Chatterjee, Kenneth A. Foon

      Pages 157-173

   7. Pox Viral Vaccines

      • James L. Gulley, Philip M. Arlen, Jeffrey Schlom

      Pages 175-191

   8. Utility of Adenovirus-Based Vectors for Multiple Cancer Vaccine Approaches

      • Zachary Hartman, Andrea Amalfitano

      Pages 193-202

   9. Alphaviral-Based Strategies for the Immunotherapy of Cancer

      • Edward L. Nelson, Jonathan Smith

      Pages 203-224

   10. DNA Vaccines

       • Michael Bereta, Howard L. Kaufman

       Pages 225-248

   11. Whole-Tumor-Cell Vaccines

       • Timothy M. Clay, Paul J. Mosca, H. Kim Lyerly, Michael A. Morse

       Pages 249-251

An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.

• Antigen
• DNA
• cancer
• cell
• clinical trial
• cytokine
• cytokines
• immunotherapy
• melanoma
• ovarian cancer
• prostate cancer
• proteins
• tumor
• vaccine

"This is an excellent resource for anyone interested in tumor immunotherapy. It is truly a comprehensive review of vaccination strategies for the treatment of cancer. The third section looks at the results of vaccine-based clinical trials for various malignancies. This section is an exceptional reference for oncologists. The chapters on melanoma are particularly helpful in sorting through the saga of vaccination for this deadly disease. The concluding section, important for clinical researchers, focuses on clinical trial design, the analysis of immune responses, and vaccine regulatory issues. " -Doody's Health Sciences Book Review Journal

"Highly recommended for medical schools and hospital libraries." - E-STREAMS

"...Comprehensive and authoritative...makes available to medical oncologists and immunologists a cutting-edge synthesis of the scientific rationale, preclinical data, and clinical results for the powerful new generation of vaccines now under development and treatment of a wide range of human cancers." - Tumori

• Duke University Medical Center, Durham, USA

  Michael A. Morse, Timothy M. Clay, H. Kim Lyerly

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