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Molecular Neurosurgery with Targeted Toxins

Editors: Wiley, Ronald G., Lappi, Douglas A. (Eds.)

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About this book

The use of targeted cytotoxins to make highly selective neural lesions for both experimental and clinical purposes has already provided important animal models for diseases such as Alzheimer's, and holds great promise for research and clinical application to pain. In Molecular Neurosurgery With Targeted Toxins, pioneers in the field describe their hands-on experience with the experimental use of these toxins. The authors focus on the highly successful use of the immunotoxins, 192 IgG-saporin and ME20.4-saporin, to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals. Also discussed are the uses of anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of central nervous system demyelination. Overview perspectives and, in some cases, more practical details are provided that allow the reader to appreciate exactly what is involved in using these agents.
Both practical and theoretical, Molecular Neurosurgery With Targeted Toxins provides readers with not only the background to understand these techniques, but also numerous real-life examples that can be readily adapted to new purposes and an ever-increasing number of new targeted toxins.

Reviews

"...a good purchase for most neuroscience and neurology libraries." - Doody's Health Science Book Review Journal

Table of contents (13 chapters)

Table of contents (13 chapters)
  • Introduction to Molecular Neurosurgery

    Pages 1-8

    Wiley, Ronald G. (et al.)

  • Ribosome-Inactivating Proteins

    Pages 9-29

    Stirpe, Fiorenzo, MD

  • Biochemical, Physiological, and Behavioral Characterizations of the Cholinergic Basal Forebrain Lesion Produced by 192 IgG-Saporin

    Pages 31-58

    Waite, Jerene J.

  • Basal Forebrain Cholinergic Lesion by 192 IgG-Saporin

    Pages 59-86

    Schliebs, Reinhard

  • 192 IgG-Saporin-Induced Partial Cortical Cholinergic Deafferentation as a Model for Determining the Interactions Between Brain Aging and Neurodevelopmental Defects in the Cortical Cholinergic Input System

    Pages 87-100

    Sarter, Martin (et al.)

Buy this book

eBook $169.00
price for USA in USD
  • ISBN 978-1-59259-896-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-1-58829-199-8
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-1-61737-420-3
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Neurosurgery with Targeted Toxins
Editors
  • Ronald G. Wiley
  • Douglas A. Lappi
Copyright
2005
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-896-0
DOI
10.1007/978-1-59259-896-0
Hardcover ISBN
978-1-58829-199-8
Softcover ISBN
978-1-61737-420-3
Edition Number
1
Number of Pages
XII, 312
Topics

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