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Cancer Chemoprevention

Volume 1: Promising Cancer Chemopreventive Agents

  • Book
  • © 2004

Overview

Editors:
  1. Gary J. Kelloff

    1. National Institutes of Health, Rockville, USA

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  2. Ernest T. Hawk

    1. National Institutes of Health, Rockville, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Caroline C. Sigman

    1. CCS Associates, Mountain View, USA

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Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (43 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Antimutagens

    1. Front Matter

      Pages 1-1
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    2. Inducers of Enzymes That Protect Against Carcinogens and Oxidants

      • Thomas W. Kensler, Paul Talalay
      Pages 3-20

    3. Chemoprevention by Isothiocyanates

      • Stephen S. Hecht
      Pages 21-35

    4. Antigenotoxic and Cancer Preventive Mechanisms of N-Acetyl-l-Cysteine

      • Silvio De Flora, Alberto Izzotti, Adriana Albini, Francesco D’Agostini, Maria Bagnasco, Roumen Balansky
      Pages 37-67

    5. Modifiers of Cytochrome(s) P450

      • John DiGiovanni, Heather E. Kleiner
      Pages 69-84

  3. Antiinflammatories

    1. Front Matter

      Pages 85-85
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    2. Antiinflammatories and Chemoprevention

      • Gary B. Gordon, Gary J. Kelloff, Caroline C. C. Sigman
      Pages 87-105

    3. Cyclooxygenase-2 Inhibitors and Colorectal Cancer Prevention

      • Raymond N. DuBois
      Pages 107-113

    4. Lipoxygenases as Targets for Cancer Prevention

      • Susan M. Fischer, Russell D. Klein
      Pages 115-131

    5. Inducible Nitric Oxide Synthase as a Target for Chemoprevention

      • Lorne J. Hofseth, Tomohiro Sawa, S. Perwez Hussain, Curtis C. Harris
      Pages 133-151

    6. Chemoprevention of Cancer of the Respiratory Tract by Agents Delivered by Aerosol

      • Timothy S. Wiedmann, Lee W. Wattenberg
      Pages 153-167

    7. Chemoprevention of Cancer by Curcumin

      • Bandaru S. Reddy, Chinthalapally V. Rao
      Pages 169-175

    8. Prostacyclin and Lung Cancer Chemoprevention

      • Robert L. Keith, York E. Miller, Paul A. Bunn Jr., Patrick Nana-Sinkam, Raphael A. Nemenoff, Mark W. Geraci
      Pages 177-191

  4. Nuclear Receptor Superfamily

    1. Front Matter

      Pages 193-193
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    2. Nuclear Receptor Superfamily

      • Julia A. Lawrence, Kapil Dhingra
      Pages 195-208

    3. Antiandrogens

      1. Prostate Cancer Chemoprevention
        • Jennifer E. Drisko, Siu-Long Yao
        Pages 211-218
      2. Searching For SARA
        • Mark S. Chapman, William Y. Chang, Andres Negro-Vilar, Jeffrey N. Miner
        Pages 219-228

    4. Antiestrogens

      1. Aromatase Inhibitors as Chemopreventives of Breast Cancer
        • Mitchell Dowsett, Judy E. Garber
        Pages 231-243
      2. Breast Cancer Chemoprevention by Selective Estrogen Receptor Modulators
        • Carolyn L. Smith
        Pages 245-256
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Keywords

About this book

Much progress has been made in discovering and developing agents that have promise, or have already been successfully used, to treat precancerous conditions or inhibit carcinogenesis. In Cancer Chemoprevention, Volume 1: Promising Cancer Chemopreventive Agents, leading researchers in the discovery and development of chemopreventives comprehensively survey all aspects of these emerging therapeutics. For each agent, the authors review the relevant mechanisms of action, the criteria for populations benefiting from intervention, the safety and pharmacodynamics, clinical study design emphasizing the use of precancers, and early associated cellular and molecular biomarkers of carcinogenesis. The pharmacologic and/or mechanistic classes discussed range from antimutagens, antiinflammatories, and the nuclear receptor superfamily, to signal transduction modulators, antioxidants, vitamins, and minerals. The classes vary widely in terms of their stages of development as chemopreventives and include both extensively studied groups and those with recently identified potential based on such mechanistic data as protein kinase inhibition. Attention is also devoted to nutriceuticals (food-derived agents) because of their high promise for prevention in healthy populations. The overall focus is on molecular targets and mechanisms. A second volume, Strategies for Cancer Chemoprevention, describes the exciting methodologies that are accelerating progress in this field and discusses the state of clinical development of chemoprevention in the various human cancer target organs.
Up-to-date and highly practical, Cancer Chemoprevention, Volumes 1 & 2, offer oncologists, pharmacologists, medicinal chemists, and toxicologists a comprehensive reference survey on the identification of promising cancer chemopreventive agents that will help stimulate further research and the development of novel approvable drugs.

Reviews

"...a comprehensive review of seizures...a wealth of information." - British Journal of Anesthesiology

"...a valuable addition to any library in a lboratory researching/developing oncology products..." - BTS Newsletter

"...provides a comprehensive reference survey for basic researchers, pharmacologists and clinical oncologists...a must for everyone involved in chemoprevention research." - Annals of Oncology

Editors and Affiliations

  • National Institutes of Health, Rockville, USA

    Gary J. Kelloff, Ernest T. Hawk

  • CCS Associates, Mountain View, USA

    Caroline C. Sigman

Bibliographic Information

  • Book Title: Cancer Chemoprevention

  • Book Subtitle: Volume 1: Promising Cancer Chemopreventive Agents

  • Editors: Gary J. Kelloff, Ernest T. Hawk, Caroline C. Sigman

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59259-767-3

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2004

  • Hardcover ISBN: 978-1-58829-076-2Published: 04 June 2004

  • Softcover ISBN: 978-1-61737-342-8Published: 19 November 2010

  • eBook ISBN: 978-1-59259-767-3Published: 04 June 2004

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XVI, 697

  • Number of Illustrations: 58 b/w illustrations, 1 illustrations in colour

  • Topics: Oncology

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