Cancer Drug Discovery and Development

Cancer Chemoprevention

Volume 1: Promising Cancer Chemopreventive Agents

Editors: Kelloff, Gary J., Hawk, Ernest T., Sigman, Caroline C. (Eds.)

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About this book

Much progress has been made in discovering and developing agents that have promise, or have already been successfully used, to treat precancerous conditions or inhibit carcinogenesis. In Cancer Chemoprevention, Volume 1: Promising Cancer Chemopreventive Agents, leading researchers in the discovery and development of chemopreventives comprehensively survey all aspects of these emerging therapeutics. For each agent, the authors review the relevant mechanisms of action, the criteria for populations benefiting from intervention, the safety and pharmacodynamics, clinical study design emphasizing the use of precancers, and early associated cellular and molecular biomarkers of carcinogenesis. The pharmacologic and/or mechanistic classes discussed range from antimutagens, antiinflammatories, and the nuclear receptor superfamily, to signal transduction modulators, antioxidants, vitamins, and minerals. The classes vary widely in terms of their stages of development as chemopreventives and include both extensively studied groups and those with recently identified potential based on such mechanistic data as protein kinase inhibition. Attention is also devoted to nutriceuticals (food-derived agents) because of their high promise for prevention in healthy populations. The overall focus is on molecular targets and mechanisms. A second volume, Strategies for Cancer Chemoprevention, describes the exciting methodologies that are accelerating progress in this field and discusses the state of clinical development of chemoprevention in the various human cancer target organs.
Up-to-date and highly practical, Cancer Chemoprevention, Volumes 1 & 2, offer oncologists, pharmacologists, medicinal chemists, and toxicologists a comprehensive reference survey on the identification of promising cancer chemopreventive agents that will help stimulate further research and the development of novel approvable drugs.

Reviews

"...a comprehensive review of seizures...a wealth of information." - British Journal of Anesthesiology

"...a valuable addition to any library in a lboratory researching/developing oncology products..." - BTS Newsletter

"...provides a comprehensive reference survey for basic researchers, pharmacologists and clinical oncologists...a must for everyone involved in chemoprevention research." - Annals of Oncology

Table of contents (43 chapters)

  • Inducers of Enzymes That Protect Against Carcinogens and Oxidants

    Kensler, Thomas W., PhD, DABT (et al.)

    Pages 3-20

  • Chemoprevention by Isothiocyanates

    Hecht, Stephen S., PhD

    Pages 21-35

  • Antigenotoxic and Cancer Preventive Mechanisms of N-Acetyl-l-Cysteine

    Flora, Silvio, MD (et al.)

    Pages 37-67

  • Modifiers of Cytochrome(s) P450

    DiGiovanni, John, PhD (et al.)

    Pages 69-84

  • Antiinflammatories and Chemoprevention

    Gordon, Gary B., MD, PhD (et al.)

    Pages 87-105

Buy this book

eBook $269.00
price for USA in USD (gross)
  • ISBN 978-1-59259-767-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $349.99
price for USA in USD
  • ISBN 978-1-58829-076-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $349.99
price for USA in USD
  • ISBN 978-1-61737-342-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cancer Chemoprevention
Book Subtitle
Volume 1: Promising Cancer Chemopreventive Agents
Editors
  • Gary J. Kelloff
  • Ernest T. Hawk
  • Caroline C. Sigman
Series Title
Cancer Drug Discovery and Development
Copyright
2004
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-59259-767-3
DOI
10.1007/978-1-59259-767-3
Hardcover ISBN
978-1-58829-076-2
Softcover ISBN
978-1-61737-342-8
Series ISSN
2196-9906
Edition Number
1
Number of Pages
XVI, 697
Number of Illustrations
58 b/w illustrations, 1 illustrations in colour
Topics