Innate Immunity

1. Front Matter

   Pages i-xi

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2. Plant Immunity

   1. Front Matter

      Pages 1-2

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   2. Pathogen Recognition and Signal Transduction in Plant Immunity

      • Jonathan Cohn, Gregory B. Martin

      Pages 3-26

   3. Plant Disease Resistance Genes

      • Jeffrey G. Ellis, David A. Jones

      Pages 27-45

   4. Nonhost Resistance in Plants to Microbial Pathogens

      • Michèle C. Heath

      Pages 47-57

3. Invertebrate Host Defense Immunity

   1. Front Matter

      Pages 59-60

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   2. Regulatory Co-options in the Evolution of Deuterostome Immune Systems

      • Ellen V. Rothenberg, Eric H. Davidson

      Pages 61-87

   3. Antimicrobial Peptides in Insect Immunity

      • Philippe Bulet, Maurice Charlet, Charles Hetru

      Pages 89-107

   4. Innate Immunity in the Horseshoe Crab

      • Shun-ichiro Kawabata, Tsukasa Osaki, Sadaaki Iwanaga

      Pages 109-125

   5. Pattern Recognition Receptors in Drosophila

      • Mika Rämet, Alan Pearson, Kati Baksa, Asha Harikrishnan

      Pages 127-135

   6. Humoral and Cellular Responses in Drosophila Innate Immunity

      • Julien Royet, Marie Meister, Dominique Ferrandon

      Pages 137-153

   7. Thioester-Containing Proteins of Protostomes

      • Elena A. Levashina, Stéphanie Blandin, Luis F. Moita, Marie Lagueux, Fotis C. Kafatos

      Pages 155-173

4. Mammalian Host Defenses: Pattern Recognition Receptors

   1. Front Matter

      Pages 175-176

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5. Mammalian Host Defenses: Pattern Recognition Receptors

   1. Toll-Like Receptors

      • Tsuneyasu Kaisho, Shizuo Akira

      Pages 177-189

6. Mammalian Host Defenses: Pattern Recognition Receptors

   1. The Macrophage Mannose Receptor and Innate Immunity

      • Thiruvamoor P. Ramkumar, Djilali Hammache, Philip D. Stahl

      Pages 191-204

   2. Diverse Roles of Lung Collectins in Pulmonary Innate Immunity

      • Erika C. Crouch, Jeffrey A. Whitsett

      Pages 205-229

   3. Structures of Complement Control Proteins

      • Thilo Stehle, Mykol Larvie

      Pages 231-253

   4. Lipopolysaccharide-Binding Protein and CD14

      • Peter S. Tobias

      Pages 255-265

7. Mammalian Host Defenses: Links Between Innate and Adaptive Immunity

   1. Front Matter

      Pages 267-268

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8. Mammalian Host Defenses: Links Between Innate and Adaptive Immunity

   1. The Role of Chemokines in Linking Innate and Adaptive Immunity

      • Cory M. Hogaboam, Steven L. Kunkel

      Pages 269-286

The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to playa key role in stimulating the subsequent clonal response of adaptive immunity. Recent exciting information has determined that the templates that are laid down in primitive life forms, like flowering plants and insects, form the basic principles of first­ line host defense that are conserved in mammalian systems. The next frontier in the field is to understand the dynamic adaptive changes that occur as a result of the inter­ play between host defenses and infectious agents. One emerging theme is that microorganisms are constantly seeking ways to co-opt host defenses. On the other hand, host defense to infection is mediated by the coordinate action of pattern recognition molecules and receptors that, in mammals, are important and probably necessary antecedents to the development of an adaptive immune response. Innate Immunity aims to explore the intersection between host pathogen interactions across an evolutionary spectrum that will inform our understanding of the dynamic interplay between infectious agents and host defense in man.

• Chemokine
• infection
• innate immunity
• proteins
• resistance

• Laboratory of Developmental Immunology, Massachusetts General Hospital, Boston, USA

  R. Alan B. Ezekowitz

• Department of Pediatrics, Harvard Medical School, Boston, USA

  R. Alan B. Ezekowitz

• Institute of Molecular and Cellular Biology, CNRS, Strasbourg, France

  Jules A. Hoffmann

Policies and ethics