Clinical Benefits of Leukodepleted Blood Products

1. Front Matter

   Pages N2-x

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2. Introduction

   • Joseph Sweeney, Andrew Heaton

   Pages 1-3

3. Methods of Leukodepletion

   • Barry Wenz

   Pages 5-16

4. Enumeration of Low White Cells

   • Girolamo Sirchia, Paolo Rebulla

   Pages 17-27

5. Mechanisms of Leukodepletion by Filtration

   • Ingeborg Steneker, Ruby N. I. Pietersz, Henk W. Reesink

   Pages 29-42

6. Role of Contaminating White Blood Cells in the Storage Lesions of Red Cells and Platelets

   • Joseph D. Sweeney, Stein Holme, Andrew Heaton

   Pages 43-59

7. Leukodepletion to Prevent Transfusion Reactions: Effects on Cytokines and Other Biologic Response Modifiers

   • Gary Stack, Edward L. Snyder

   Pages 61-80

8. Leukodepletion and Alloimmunization

   • Irena Sniecinski

   Pages 81-96

9. Role of Donor Leukocytes and Leukodepletion in Transfusion-Associated Viral Infections

   • Michael P. Busch, Tzong-Hae Lee

   Pages 97-112

10. Leukocyte Depletion and Transfusion-Induced Immunomodulation

    • Darrell J. Triulzi, Neil Blumberg

    Pages 113-127

11. The Role of Leukocyte Depletion In Prevention of Transfusion-Related Acute Lung Injury

    • Mark A. Popovsky

    Pages 129-135

12. The Role of Leukocyte Depletion in the Prevention of Reperfusion Injury Associated with Open Heart Surgery

    • Terry Gourlay, Kenneth M. Taylor

    Pages 137-151

13. The Use of Leukodepleted Blood Components for Neonates and Infants

    • Naomi L. C. Luban, Louis DePalma

    Pages 153-165

14. Leukocyte Depleted Blood Transfusion in Hematopoietic Stem Cell Reconstitution Therapy

    • John P. Miller, Paul D. Mintz

    Pages 167-181

15. Cost-Effectiveness of Leukodepletion

    • John M. Forbes, Maren A. Anderson, Steven A. Gould

    Pages 183-191

16. Back Matter

    Pages 193-201

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Joseph Sweeney, Andrew Heaton he presence of allogeneic leukocytes in blood products received little T attention until the mid-1950s when these "passenger" cells were im­ plicated in the etiology of febrile transfusion reactions, and early strate­ gies based on centrifugation were developed to effect their removal. In recent decades and, particularly in the past five years, there has been an accumulation of literature implicating leukocytes in a wide variety of undesirable reactions to blood transfusion. White cells are the least numerous of the cellular elements in blood and ratios of white cells to platelets and white cells to red cells are ap­ proximately 1:15 to 1:1000 respectively. This ratio is maintained in whole blood, but may be altered slightly in the process of component prepara­ tion. Any production or processing step which intentionally decreases this ratio will result in a product which can be described as white cell depleted. It has, however, become more common to define the outcome as a residual white cell content, rather than a decrease in cellular ratios, although the latter makes more sense on theoretical grounds, since deple­ tion of white cells needs to be put in the context of any unintentional loss of red cells or platelets. The end result of this intentional processing step, therefore, is generally expressed as the residual absolute number of white cells or as the degree of difference in white cell content, the latter expressed as either a percentage change or as a logarithmic reduction.

• attention
• blood
• blood cell
• cell
• cells
• cytokine
• cytokines
• heart
• immunization
• immunomodulation
• lung
• production
• research
• stem cell
• viral infection

• The Miriam and Roger Williams Hospitals, Providence, USA

  Joseph Sweeney

• Irwin Memorial Blood Center, San Francisco, USA

  Andrew Heaton

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