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Methods in Physiology

Omics Approaches to Understanding Muscle Biology

Editors: Burniston, Jatin George, Chen, Yi-Wen (Eds.)

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  • Comprises research, that spans all levels of biological organisation, including DNA, RNA, protein and metabolite
  • Combines different OMICS approaches under the unifying theme of skeletal muscle physiology
  • Broadens the understanding of big data usage in physiology research
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eBook $129.00
price for USA in USD (gross)
  • ISBN 978-1-4939-9802-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-1-4939-9801-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book is a collection of principles and current practices in omics research, applied to skeletal muscle physiology and disorders. The various sections are categorized according to the level of biological organization, namely, genomics (DNA), transcriptomics (RNA), proteomics (protein), and metabolomics (metabolite). With skeletal muscle as the unifying theme, and featuring contributions from leading experts in this traditional field of research, it highlights the importance of skeletal muscle tissue in human development, health and successful ageing. It also discusses other fascinating topics like developmental biology, muscular dystrophies, exercise, insulin resistance and atrophy due to disuse, ageing or other muscle diseases, conveying the vast opportunities for generating new hypotheses as well as testing existing hypotheses by combining high-throughput techniques with proper experiment designs, bioinformatics and statistical analyses.

Presenting the latest research techniques, this book is a valuable resource for the physiology community, particularly researchers and grad students who want to explore the new opportunities for omics technologies in basic physiology research.

 

About the authors

Jatin Burniston is a Professor of Muscle Proteomics at the Research Institute for Sport & Exercise Sciences, Liverpool John Moores University, UK. He established the first proteomics facility with a specific focus on exercise physiology and published the first works reporting proteomic analysis of striated muscle responses to exercise training. Jatin strives to continue pioneering the field of exercise proteomics and is a proud champion of the application of non-targeted '-omic' research in exercise physiology. He recently combined his expertise in mass spectrometry and proteomics with new metabolic labelling methods using deuterated/ ‘heavy’ water to establish the unique ‘Dynamic Proteome Profiling’ method. Jatin serves on the Editorial Board of the American Physiological Society (APS) journal, Physiological Genomics, and is a Fellow of the European College of Sports Sciences (ECSS) and a member of the ECSS Scientific Committee. He also leads the MSc Exercise Physiology programme at Liverpool John Moores and particularly enjoys delivering his module on Molecular Exercise Physiology.
Yi-Wen Chen is an Associate Professor of Genomics and Precision Medicine at the George Washington University and Principal Investigator at the Center for Genetic Medicine Research, Children’s National Health System, DC, USA. Her research uses transcriptomic approaches to study molecular pathways in muscles in response to physiological stimuli and pathological conditions. Yi-Wen uses genome-wide RNA profiling to dissect the disease mechanisms of various muscle disorders and to identify molecular mechanisms of adaptive remodelling. In addition, her group uses next-generation sequencing and long-read sequencing to study genetic, epigenetic and transcriptomic changes in muscles using physiological and disease models. Currently she is part of the Human Cell Atlas consortium, with a focus on single-cell profiles and spatial characterization of gene expression in skeletal muscles at different developmental stages.

Table of contents (10 chapters)

Table of contents (10 chapters)

Buy this book

eBook $129.00
price for USA in USD (gross)
  • ISBN 978-1-4939-9802-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-1-4939-9801-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Omics Approaches to Understanding Muscle Biology
Editors
  • Jatin George Burniston
  • Yi-Wen Chen
Series Title
Methods in Physiology
Copyright
2019
Publisher
Springer US
Copyright Holder
The American Physiological Society
eBook ISBN
978-1-4939-9802-9
DOI
10.1007/978-1-4939-9802-9
Hardcover ISBN
978-1-4939-9801-2
Edition Number
1
Number of Pages
VII, 217
Number of Illustrations
3 b/w illustrations, 32 illustrations in colour
Topics