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Methods in Molecular Biology

Oligonucleotide-Based Therapies

Methods and Protocols

Editors: Gissberg, Olof, Zain, Rula, Lundin, Karin E. (Eds.)

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  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts
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eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-4939-9670-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-1-4939-9669-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book provides a collection of comprehensive, up-to-date, and broadly applicable guides to the research and development fields of oligonucleotide (ON) therapeutics. Covering topics from the study of antisense and anti-gene effects to oligonucleotides in the context of drug discovery and development, the volume explores a wide-ranging and useful spectrum of methods and protocols needed to take full advantage of therapeutic applications involving ONs. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 
Authoritative and practical, Oligonucleotide-Based Therapies: Methods and Protocols aims to be a great aid in the laboratory as well as an ideal reference guide when designing antisense and anti-gene oligonucleotides for therapeutic applications.

Table of contents (19 chapters)

Table of contents (19 chapters)
  • Chemical Development of Therapeutic Oligonucleotides

    Pages 3-16

    Lundin, Karin E. (et al.)

  • Tissue-Specific Delivery of Oligonucleotides

    Pages 17-50

    Xia, Xin (et al.)

  • Designing siRNA and Evaluating Its Effect on RNA Targets Using qPCR and Western Blot

    Pages 53-72

    Vidarsdottir, Linda (et al.)

  • Antisense Oligonucleotides for Splice Modulation: Assessing Splice Switching Efficacy

    Pages 73-90

    Rocha, Cristina S. J.

  • Assessing Oligonucleotide Binding to Double-Stranded DNA

    Pages 91-112

    Mozafari, Negin (et al.)

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-4939-9670-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-1-4939-9669-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Oligonucleotide-Based Therapies
Book Subtitle
Methods and Protocols
Editors
  • Olof Gissberg
  • Rula Zain
  • Karin E. Lundin
Series Title
Methods in Molecular Biology
Series Volume
2036
Copyright
2019
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC, part of Springer Nature
eBook ISBN
978-1-4939-9670-4
DOI
10.1007/978-1-4939-9670-4
Hardcover ISBN
978-1-4939-9669-8
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XI, 344
Number of Illustrations
23 b/w illustrations, 46 illustrations in colour
Topics