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Methods in Molecular Biology

DNA Repair

Methods and Protocols

Editors: Balakrishnan, Lata, Stewart, Jason (Eds.)

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
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eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-4939-9500-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-1-4939-9499-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The volume outlines techniques used to study the primary mechanisms of important DNA repair pathways. The chapters in this book are organized into five sections, each discussing a specific aspect of repair biology. Part I reviews the role of post-translational modifications of HDR, and DNA damage caused by defective telomere replication. Part II describes methods to detect and measure DNA breaks and proteins involved in DNA damage response. Part III talks about methods designed to measure DNA repair efficiency and characterize factors involved in the repair process. Part IV discusses various in vitro assays used to purify recombinant proteins that are used to study DNA repair enzyme mechanisms. Lastly, Part V focuses on methods to study the damage arising during DNA replication. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and authoritative, DNA Repair: Methods and Protocols is an essential resource for novice and experienced researchers, and provides easily adaptable techniques to help them advance in their specific protein or repair pathway of interest.


Table of contents (24 chapters)

Table of contents (24 chapters)
  • Homologous Recombination-Mediated DNA Repair and Implications for Clinical Treatment of Repair Defective Cancers

    Pages 3-29

    Reilly, Nicole M. (et al.)

  • Resolving Roadblocks to Telomere Replication

    Pages 31-57

    Mason-Osann, Emily (et al.)

  • In Time and Space: Laser Microirradiation and the DNA Damage Response

    Pages 61-74

    Kim, Jae Jin (et al.)

  • Quantification of Double-Strand Breaks in Mammalian Cells Using Pulsed-Field Gel Electrophoresis

    Pages 75-85

    Pond, Kelvin W. (et al.)

  • Methods to Study Trinucleotide Repeat Instability Induced by DNA Damage and Repair

    Pages 87-101

    Lai, Yanhao (et al.)

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-4939-9500-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-1-4939-9499-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
DNA Repair
Book Subtitle
Methods and Protocols
Editors
  • Lata Balakrishnan
  • Jason Stewart
Series Title
Methods in Molecular Biology
Series Volume
1999
Copyright
2019
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC, part of Springer Nature
eBook ISBN
978-1-4939-9500-4
DOI
10.1007/978-1-4939-9500-4
Hardcover ISBN
978-1-4939-9499-1
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XV, 352
Number of Illustrations
29 b/w illustrations, 64 illustrations in colour
Topics