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Chiral Separations

Methods and Protocols

  • Book
  • © 2019

Overview

Editors:
  1. Gerhard K. E. Scriba

    1. Department of Pharmaceutical Chemistry, University of Jena, Jena, Germany

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  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1985)

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Table of contents (27 protocols)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Recognition Mechanisms of Chiral Selectors: An Overview

    • Gerhard K. E. Scriba
    Pages 1-33

  3. Enantioseparation by Thin-Layer Chromatography

    • Rituraj Dubey, Ravi Bhushan
    Pages 35-44

  4. Enantioseparations by Gas Chromatography Using Porous Organic Cages as Stationary Phase

    • Sheng-Ming Xie, Jun-Hui Zhang, Li-Ming Yuan
    Pages 45-55

  5. Chiral Metabolomics Using Triazine-Based Chiral Labeling Reagents by UPLC-ESI-MS/MS

    • Toshimasa Toyo’oka
    Pages 57-79

  6. Chiral Mobile-Phase Additives in HPLC Enantioseparations

    • Lushan Yu, Shengjia Wang, Su Zeng
    Pages 81-91

  7. Polysaccharide-Based Chiral Stationary Phases for Enantioseparations by High-Performance Liquid Chromatography: An Overview

    • Bezhan Chankvetadze
    Pages 93-126

  8. HPLC Enantioseparations with Polysaccharide-Based Chiral Stationary Phases in HILIC Conditions

    • Roberto Cirilli
    Pages 127-146

  9. Functional Cyclodextrin-Clicked Chiral Stationary Phases for Versatile Enantioseparations by HPLC

    • Jie Zhou, Jian Tang, Weihua Tang
    Pages 147-157

  10. HPLC Enantioseparation on Cyclodextrin-Based Chiral Stationary Phases

    • Xiaoxuan Li, Yong Wang
    Pages 159-169

  11. Hybrid Organic-Inorganic Materials Containing a Nanocellulose Derivative as Chiral Selector

    • Liang Zhao, Hui Li, Shuqing Dong, Yanping Shi
    Pages 171-181

  12. Cyclofructans as Chiral Selectors: An Overview

    • Garrett Hellinghausen, Daniel W. Armstrong
    Pages 183-200

  13. High-Performance Liquid Chromatography Enantioseparations Using Macrocyclic Glycopeptide-Based Chiral Stationary Phases: An Overview

    • István Ilisz, Tímea Orosz, Antal Péter
    Pages 201-237

  14. Application of Sub-2 Micron Particle Silica Hydride Derivatized with Vancomycin for Chiral Separations by Nano-Liquid Chromatography

    • Chiara Fanali, Salvatore Fanali
    Pages 239-250

  15. Cinchona Alkaloid-Based Zwitterionic Chiral Stationary Phases Applied for Liquid Chromatographic Enantiomer Separations: An Overview

    • István Ilisz, Attila Bajtai, Antal Péter, Wolfgang Lindner
    Pages 251-277

  16. Enantioseparations by High-Performance Liquid Chromatography Based on Chiral Ligand Exchange

    • Federica Ianni, Lucia Pucciarini, Andrea Carotti, Roccaldo Sardella, Benedetto Natalini
    Pages 279-302

  17. Applications of Chiral Supercritical Fluid Chromatography

    • Emmanuelle Lipka
    Pages 303-319

  18. Chiral Separations by Countercurrent Chromatography

    • Sheng-Qiang Tong
    Pages 321-337

  19. Cyclodextrins as Chiral Selectors in Capillary Electrophoresis Enantioseparations

    • Gerhard K. E. Scriba, Pavel Jáč
    Pages 339-356

  20. Application of Dual-Cyclodextrin Systems in Capillary Electrophoresis Enantioseparations

    • Anne-Catherine Servais, Marianne Fillet
    Pages 357-364
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Keywords

About this book

This detailed book focuses on analytical separations by chromatographic and electrophoretic techniques, providing some overview along with numerous practically-oriented applications of the most important analytical techniques in chiral separation sciences. While some compounds may only be enantioseparated with one technique based on the physico-chemical properties, often the analyst can choose between two or more analytical techniques for a given analyte, which requires knowledge of the strengths and weaknesses of each technique in order to select the most appropriate method for the given problem. This collection binds that knowledge in one volume. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, Chiral Separations: Methods and Protocols, Third Edition serves as a helpful guide for analytical chemists working on stereochemical problems in the fields of pharmacy, chemistry, biochemistry, food chemistry, molecular biology, forensics, environmental sciences, or cosmetics in academia, government, or industry.

Reviews

“The book is aimed at investigators in any discipline working in the field of chirality. It will be of special interest to anyone who has a need to separate chiral molecules. … Detailed protocols are provided for the systems covered in the book that will make it easier for investigators wishing to replicate one of these procedures.” (Thomas J. Wenzel, Analytical and Bioanalytical Chemistry, Vol. 411, 2019)

Editors and Affiliations

  • Department of Pharmaceutical Chemistry, University of Jena, Jena, Germany

    Gerhard K. E. Scriba

Bibliographic Information

  • Book Title: Chiral Separations

  • Book Subtitle: Methods and Protocols

  • Editors: Gerhard K. E. Scriba

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-9438-0

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2019

  • Hardcover ISBN: 978-1-4939-9437-3Published: 08 May 2019

  • eBook ISBN: 978-1-4939-9438-0Published: 08 May 2019

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 3

  • Number of Pages: XIV, 487

  • Number of Illustrations: 91 b/w illustrations, 56 illustrations in colour

  • Topics: Pharmaceutical Sciences/Technology, Analytical Chemistry, Biochemistry, general

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