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Methods in Molecular Biology

Experimental Cholestasis Research

Editors: Vinken, Mathieu (Ed.)

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  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts
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eBook $169.00
price for USA in USD
  • ISBN 978-1-4939-9420-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
Softcover $149.99
price for USA in USD
About this book

This detailed book provides a state-of-the-art compilation of protocols relevant for the experimental study of cholestasis, each written by internationally recognized research teams that have built up long-standing expertise regarding one or more aspects of experimental cholestasis research. The first half of the collection examines methods targeted towards studying established and new mechanisms of cholestasis, while the second half explores experimental models and tools to investigate mechanisms of cholestasis and/or to predict cholestatic properties of drugs. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 
Authoritative and practical, Experimental Cholestasis Research serves as an ideal guide for basic and applied researchers pursuing this vital area of research in pharmacology and toxicology.

Table of contents (26 chapters)

Table of contents (26 chapters)
  • Mechanisms of Drug-Induced Cholestasis

    Pages 1-14

    Gijbels, Eva (et al.)

  • LC-MS/MS Analysis of Bile Acids in In Vitro Samples

    Pages 15-23

    Dewaele, Debbie (et al.)

  • Pipe-3D: A Pipeline Based on Immunofluorescence, 3D Confocal Imaging, Reconstructions, and Morphometry for Biliary Network Analysis in Cholestasis

    Pages 25-53

    Damle-Vartak, Amruta (et al.)

  • Vesicle- and Hepatocyte-Based Assays for Identification of Drug Candidates Inhibiting BSEP Function

    Pages 55-73

    Brantegem, Pieter (et al.)

  • The C-DILI™ Assay: An Integrated In Vitro Approach to Predict Cholestatic Hepatotoxicity

    Pages 75-85

    Jackson, Jonathan P. (et al.)

Buy this book

eBook $169.00
price for USA in USD
  • ISBN 978-1-4939-9420-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
Softcover $149.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Experimental Cholestasis Research
Editors
  • Mathieu Vinken
Series Title
Methods in Molecular Biology
Series Volume
1981
Copyright
2019
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC, part of Springer Nature
eBook ISBN
978-1-4939-9420-5
DOI
10.1007/978-1-4939-9420-5
Hardcover ISBN
978-1-4939-9419-9
Softcover ISBN
978-1-4939-9422-9
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XIII, 399
Number of Illustrations
14 b/w illustrations, 60 illustrations in colour
Topics