High-Throughput Metabolomics
Methods and Protocols
Editors: D'Alessandro, Angelo (Ed.)
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- Provides step-by-step detail essential for reproducible results
- Contains key implementation advice from the experts
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- About this book
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This detailed volume focuses on recent technological, computational, and biostatistical advances in the field of high-throughput metabolomics. Chapters encompass methods, platforms, and analytical strategies for steady state measurements and metabolic flux analysis with stable isotope-labeled tracers, in biological matrices of clinical relevance and model organisms. Mass spectrometry-based or orthogonal methods are discussed, along with computational and statistical methods to address data sparsity in high-throughput metabolomics approaches. As a part of the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, High-Throughput Metabolomics: Methods and Protocols provides tools that can bring about the next generation of clinical biochemistry in a cost-effective, rigorous fashion, exponentially advancing our capacity to investigate nature while hastening the advent of personalized medicine.
- Table of contents (27 chapters)
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Sample Preparation and Reporting Standards for Metabolomics of Adherent Mammalian Cells
Pages 3-12
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High-Throughput Metabolomics: Isocratic and Gradient Mass Spectrometry-Based Methods
Pages 13-26
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High-Throughput Metabolomics Based on Direct Mass Spectrometry Analysis in Biomedical Research
Pages 27-38
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Traveling Wave Ion Mobility Mass Spectrometry: Metabolomics Applications
Pages 39-53
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Capillary Electrophoresis Mass Spectrometry as a Tool for Untargeted Metabolomics
Pages 55-77
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Table of contents (27 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- High-Throughput Metabolomics
- Book Subtitle
- Methods and Protocols
- Editors
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- Angelo D'Alessandro
- Series Title
- Methods in Molecular Biology
- Series Volume
- 1978
- Copyright
- 2019
- Publisher
- Humana Press
- Copyright Holder
- Springer Science+Business Media, LLC, part of Springer Nature
- eBook ISBN
- 978-1-4939-9236-2
- DOI
- 10.1007/978-1-4939-9236-2
- Hardcover ISBN
- 978-1-4939-9235-5
- Series ISSN
- 1064-3745
- Edition Number
- 1
- Number of Pages
- XV, 459
- Number of Illustrations
- 20 b/w illustrations, 63 illustrations in colour
- Topics
