Methods in Molecular Biology

Beta-Arrestins

Methods and Protocols

Editors: Scott, Mark G H, Laporte, Stephane A. (Eds.)

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
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About this book

This volume looks at various approaches to study the pleiotropic roles of b-arrestins (b-arrs) in the control of signal transduction, and the resulting cellular and in vivo consequences that arise. The chapters in this book cover diverse topics around b-arrs such as their established roles in GPCR regulation and trafficking; regulatory scaffolding functions of b-arrs in  MAPK signaling, cAMP hydrolysis and cytoskeletal dynamics; proteomic analysis of the b-arr interactome; mathematical modelling of b-arr signaling networks; functional selectivity involving biased ligands; nucleocytoplasmic trafficking and primary cilia-associated functions of b-arrs; conformational plasticity of b-arrs; and the roles of b-arrs in allergic inflammation, Type 2 Diabetes, Parkinson’s disease, and cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.


Cutting-edge and authoritative, Beta-Arrestins: Methods and Protocols is a valuable resource for researchers interested in learning more about the function and regulation of b-arrestins.


Table of contents (25 chapters)

Table of contents (25 chapters)
  • A Brief History of the β-Arrestins

    Pages 3-8

    Caron, Marc G. (et al.)

  • β-Arrestins: Multitask Scaffolds Orchestrating the Where and When in Cell Signalling

    Pages 9-55

    Laporte, Stéphane A. (et al.)

  • Methods to Monitor the Trafficking of β-Arrestin/G Protein-Coupled Receptor Complexes Using Enhanced Bystander BRET

    Pages 59-68

    Cao, Yubo (et al.)

  • Methods to Investigate β-Arrestin-Mediated Regulation of GPCR Function in Human Airway Smooth Muscle

    Pages 69-82

    Pera, Tonio (et al.)

  • Measuring Recruitment of β-Arrestin to G Protein-Coupled Heterodimers Using Bioluminescence Resonance Energy Transfer

    Pages 83-91

    Fillion, Dany (et al.)

Buy this book

eBook $169.00
price for USA in USD
  • ISBN 978-1-4939-9158-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-1-4939-9157-0
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Beta-Arrestins
Book Subtitle
Methods and Protocols
Editors
  • Mark G H Scott
  • Stephane A. Laporte
Series Title
Methods in Molecular Biology
Series Volume
1957
Copyright
2019
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC, part of Springer Nature
eBook ISBN
978-1-4939-9158-7
DOI
10.1007/978-1-4939-9158-7
Hardcover ISBN
978-1-4939-9157-0
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XIV, 409
Number of Illustrations
19 b/w illustrations, 60 illustrations in colour
Topics